摘要
目的探讨扩散峰度成像(DKI)主要的3个参数对外周带前列腺癌的诊断价值。方法对40例外周带前列腺癌患者进行常规MRI扫描和DKI序列扫描,以病理检测为金标准,观测指标包括外周带肿瘤区域和非肿瘤区域平均表观扩散系数(ADC)值、各项异性(FA)值及平均峰度(MK)值。应用双样本t检验比较肿瘤区域和非肿瘤区域间DKI各参数值的差异,应用ROC曲线分析DKI各参数对外周带前列腺癌的诊断效能。结果外周带前列腺癌的FA及MK值均明显高于正常外周带组织,差异具有极显著性统计学意义(P<0.01),而ADC值明显低于正常组织,差异具有极显著性统计学意义(P<0.01)。DKI的3个参数(ADC值、FA值及MK值)诊断前列腺癌的ROC曲线下面积分别为0.966、0.871和0.998。结论 DKI的3个参数(ADC值、FA值及MK值)对于外周带前列腺癌均具有诊断意义,而MK值是敏感性及特异性俱佳的参数。
Objective To evaluate the application value of 3 main parameters of diffusion kurtosis imaging（DKI） in diagnosis of prostatic carcinoma in the peripheral zone.Methods Conventional MRI and DKI were performed in 40 patients with histological confirmed as prostatic carcinoma in the peripheral zone.The values of ADC,FA and MK were calculated in the patients＇ tumor center and normal areas of the peripheral zone,and compared by two samples t-test.ROC curve were carried out to analyze the ability of ADC,MK and FA in differentiating prostate carcinoma from normal tissue in the peripheral zone.Results The mean values of MK and FA were significantly higher in tumor center than those in normal areas of the peripheral zone,and the ADC values were lower in tumor center,the differences were signicant（P〈0.01）.ROC curve analysis showed that the AUC of the ADC,FA and MK values were 0.966,0.871 and 0.998,respectively.Conclusion The 3 parameters of DKI could be a potential tool in diagnosing prostate carcinoma in the peripheral zone.The MK value has the highest sensitivity and specificity.
出处
《局解手术学杂志》
2017年第5期323-326,共4页
Journal of Regional Anatomy and Operative Surgery
关键词
扩散峰度成像
前列腺癌
外周带
诊断
参数
diffusion kurtosis imaging
prostate carcinoma
peripheral zone
dignosis
parameters
