摘要
以2-[N-(N'-苄基-L-脯氨酰)氨基]二苯甲酮的甘氨酸席夫碱Ni(Ⅱ)配合物为原料,经Aldol羟甲基化,脱水,Michael加成和水解反应及离子交换层析,合成了4个(S)-β-取代-α-氨基酸衍生物,产率60%~75%,ee值90%~95%,其结构经~1H NMR和元素分析确证。
Four （S）-β-substituted-α-aminoacids, with yield of 60% - 75% and ee of 90% - 95%, were synthesized by the reaction of aldol hydroxymethylation, dehydrolation, Michael nucleophilic ad- dition and acidolysis, then isolated by cation exchange resine. The structures were confirmed by l H NMR and elemental analysis.
出处
《合成化学》
CAS
CSCD
2017年第5期425-428,共4页
Chinese Journal of Synthetic Chemistry
基金
台州职业技术学院科技创新资助项目(2016YB03)
关键词
手性诱导
配位化合物
Aldol羟甲基化
氨基酸
不对称合成
chiral induction
coordination compound
Aldol hydroxymethylation
amino acid
asym- metric synthesis
