摘要
目的了解成都市MSM人群在艾滋病暴露前预防用药（PrEP）的依从性及影响因素。方法按照随机、开放、多中心平行对照临床干预研究，于2013年7月1日至2015年9月30日按照样本量估算，采用滚雪球法招募合格的研究对象为HIV高感染风险且HIV检测结果阴性的MSM，共328人，随机化分配为每Et用药组、高危行为前后用药组和空白对照组，每3个月进行临床随访和问卷调查。评价每日用药组、高危行为前后用药组的服药依从性，并用logistic回归模型探讨PrEP服药依从性的影响因素。结果共分析141名研究对象，41．8％（59／141）PrEP服药依从性好，每日用药组和高危行为前后服药组的PrEP服药依从性分别为69．0％（49／71）、14．3％（10／70），差异有统计学意义（r=45．29，P〈0．001）。多因素logistic分析结果显示，用药方式是PrEP服药依从性的影响因素，相比于每日用药组，高危行为前后用药组的服药依从性相较差（OR=0．07，95％CI：0．03～0．16）。结论MSM人群PrEP服药依从性总体不够理想，用药方式是PrEP服药依从性的主要影响因素。
Objective To evaluate the compliancy of HIV pre-exposure prophylaxis （PREP） in men who have sex with men （MSM） in Chengdu, Sichuan province, and explore the influencing factors. Methods From 1 July 2013 to 30 September 2015, a random, open, multi-center and parallel control intervention study was conducted in 328 MSM enrolled by non-probability sampling in Chengdu. The MSM were divided into 3 groups randomly, i.e. daily group, intermittent group （before and after exposure） and control group. Clinical follow-up and questionnaire survey were carried out every 3 months. Their PrEP compliances were evaluated respectively and multivariate logistic regression analysis was conducted to identify the related factors. Results A total of 141 MSM were surveyed, in whom 59（41.8%） had good PrEP compliancy. The PrEP compliancy rate was 69.0% in daily group, higher than that in intermittent group （14.3%）, the difference had significance （χ2=45.29, P〈0.001）. Multivariate logistic analysis indicated that type of PrEP was the influencing factors of PrEP compliancy. Compared with daily group, the intermittent group had worse PrEP compliancy （OR：0.07, 95%CI： 0.03-0.16）. Conclusion The PrEP compliance of the MSM in this study was poor, the compliancy would be influenced by the type of PREP.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2017年第5期643-645,共3页
Chinese Journal of Epidemiology
