摘要
目的探讨急性脑梗死溶栓治疗的临床疗效,并归纳总结溶栓治疗的临床研究进展。方法 53例急性脑梗死患者,随机分为观察组(27例)和对照组(26例)。两组患者均采用静脉溶栓治疗,对照组患者静脉给药尿激酶,观察组患者则采用溶栓新药阿替普酶。比较两组患者神经功能评分、治疗效果及不良反应发生情况。结果观察组患者的治疗前和治疗后2 h、1 d、1周、1个月的神经功能评分分别为(28.6±7.6)、(18.3±11.4)、(16.7±12.4)、(12.6±9.5)、(12.7±7.8)分,对照组各时间点神经功能评分分别为(26.7±8.2)、(24.6±10.8)、(23.5±9.4)、(21.5±6.8)、(17.3±8.6)分;治疗前两组神经功能评分比较差异无统计学意义(P>0.05),两组治疗后各时间点的评分比较差异具有统计学意义(P<0.05)。观察组患者经溶栓治疗后总有效率92.59%显著高于对照组的69.23%,对比差异具有统计学意义(χ~2=4.722,P<0.05)。观察组患者的不良反应的总发生率为11.11%,显著低于对照组的46.15%,差异具有统计学意义(χ~2=8.016,P<0.05)。结论溶栓治疗方式针对急性脑梗死疾病疗效显著,临床上加强了对溶栓药物的相关研究,该治疗方式的临床应用前景广阔。
Objective To investigate clinical study progress by thrombolytic therapy for acute cerebral infarction, and to generalize and summarize clinical research of thrombolytic therapy. Methods A total of 53 patients with acute cerebral infarction were randomly divided into observation group （27 cases） and control group （26 cases）. Both groups received intravenous thrombolytic therapy. The control group received intravenous administration of urokinase, and the＇observation group received alteplase as a new thrombolytic drug. Comparison was made on neurological score, curative effect and incidence of adverse reactions between the two groups. Results The observation group had neurological scores before and in 2 h, 1 d, 1 week and t month after treatment respectively as （28.6 ± 7.6）, （18.3 ± 11.4）, （16.7 ± 12.4）, （12.6 ± 9.5） and （12.7 ± 7.8） points, which were respectively （26.7 ± 8.2）, （24.6 ± 10.8）, （23.5 ± 9.4）, （21.5 ± 6.8） and （17.3 ± 8.6） points. There was no statistically significant difference of neurological score before treatment between the two groups （P〉O.05）. The difference of neurological scores at each time point after treatment had statistical significance between the two groups （P〈0.05）. The observation group had obviously higher total effective rate after thrombolytic therapy as 92.59% than 69.23% in the control group, and their difference had statistical significance （X 2=4-722, P〈O.05）. The observation group had incidence of adverse reactions as 11.11%, which was much lower than 46.15% in the control group, and their difference had statistical significance （χ^2=8-016, P〈0.05）. Conclusion Thrombolytic therapy shows excellent curative effect in treating acute cerebral infarction, along with enhanced clinical research of thrombolytic drug. This method contains promising prospects of clinical application.
出处
《中国实用医药》
2017年第11期113-115,共3页
China Practical Medicine
关键词
溶栓治疗
急性脑梗死
临床研究
临床效果
Thrombolytic therapy
Acute cerebral infarction
Clinical research
Clinical effect
