摘要
目的:探讨经直肠超声电导中药透入法对小体积BPH患者组织学前列腺炎及TURP术后LUTS的疗效。方法:将2012年3月至2015年2月确诊为BPH且无手术禁忌症患者167例随机分为两组(对照组83例和试验组84例),两组患者年龄、前列腺体积、国际前列腺症状评分(IPSS)、生活质量指数评分(Qo L)之间的差异无统计学意义(P>0.05)。试验组先行经直肠超声电导中药透入治疗,每日1次,共7次,后择期行TURP;对照组常规行TURP。术后前列腺组织送病理检查,对两组患者的组织学炎症分级及术后4周IPSS、QoL评分进行比较。结果:试验组患者无炎症者12例(14.3%)、轻度炎症者43例(51.2%)、中度炎症者28例(33.3%)及重度炎症者1例(1.2%),对照组分别为8例(9.6%)、28例(33.7%)、45例(51.8%)及2例(2.4%),差异有统计学意义(P<0.05);术后4周试验组和对照组IPSS、QoL评分分别为(4.26±2.64)、(1.25±1.64)和(7.02±4.15)、(2.05±1.95)分,均较术前明显改善(P<0.05),且试验组较对照组改善更显著,差异有统计学意义(P<0.05)。结论:经直肠超声电导中药透入法能明显改善小体积BPH患者的组织学炎症及TURP术后的LUTS,提高术后生活质量,效果满意,值得临床推广。
Objective： To investigate the effects of transrectal ultrasound conductance （TRUSC）-guided administration of tra- ditional Chinese medicine on histological prostatitis in men with small-size BPH and low urinary tract symptoms （LUTS） after transure- thral resection of the prostate （TURP）. Methods ： This study included 167 BPH patients without surgical contraindications. We ran- domized the patients into an experimental group （n = 84） and a control group （n = 83 ）, with no statistically significant differences between the two groups in age, prostate volume, International Prostate Symptom Score （IPSS）, and quality of life （QoL） （P 〉 0.05）. The patients of the experimental group received TRUSC-guided administration of traditional Chinese medicine, qd, for 7 days before TURP, while those of the control group underwent TURP only. After treatment, we compared the results of postoperative pathological examination of the prostate tissue, the histological grade of inflammation, IPSS, and QoL scores between the two groups of patients. Results： In the experimental group, there were 12 cases of non-inflammation （ 14.3% ） , 43 cases of mild inflammation （51.2%） , 28 cases of moderate inflammation （33.3%） , and 1 case of severe infammation （ 1.2% ） , as compared with 8 cases of non-inflammation （9.6%） , 28 eases of mild inflammation （33.7%） , 45 cases of moderate inflammation （51.8%） , and 2 eases of severe inflammation （2.4%） in the cunh＇ol group （P 〈 0.05 ）. Compared with the baseline, both the experimental and control groups showed significant improvement at 4 weeks after surgery in IPSS （22.20 ± 4.14 vs 4.26 ±2.64 and 23.05 ±4.11 vs 7.02 ± 4. 15, P 〈0.05） and QoL scores （4.33 ±0.83 vs 1.25 ±1.64 and 4. 25 ± 0. 91vs 2. 05±1. 95 , P 〈0.05）. Conclusion： TRUSC-guided administration of traditional Chinese medicine can significantly alleviate histological inflammation and improve QoL in men with small- size BPH and LUTS after TURP.
作者
袁磊
任立江
朱国辉
王永传
张晓莉
都靖
宋吉顺
YUAN Lei REN Li-jiang ZHU Guo-huil WANG Yong-chuan ZHANG Xiao-li DU Jing SONG Ji-shun(Department of Urology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang, Shandong 262700, China Department of Urology, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2017年第5期459-463,共5页
National Journal of Andrology
关键词
良性前列腺增生
组织学前列腺炎
经尿道前列腺电切术
中药
超声电导
benign prostate hyperplasia
histological prostatitis
transurethral resection of the prostate
traditional Chinese medicine
ultrasound conductance
