摘要
目的研究双歧三联活菌联合乳果糖治疗肝硬化肠源性内毒素血症的临床效果。方法整群选择该院2014年2月—2016年9月收治的肝硬化肠源性内毒素血症患者92例为研究对象,随机分为两组。给予对照组患者常规治疗,观察组在对照组基础上接受双歧三联活菌联合乳果糖治疗。对比两组患者治疗前后血浆内毒素、肝功能及治疗效果。结果对照组患者治疗前后内毒素分别为(0.41±0.05)、(0.29±0.06)EU/m L;观察组分别为(0.40±0.06)、(0.17±0.04)EU/m L,两组患者治疗后均较治疗前有所改善,观察组改善幅度大于对照组,差异有统计学意义(P<0.05);观察组治疗后AST、ALT、TBil分别为(46.79±4.85)U/L、(46.69±5.12)U/L、(43.69±3.77)μmol/L优于对照组的(60.15±6.31)U/L、(55.81±6.45)U/L、(50.56±5.23)μmol/L,差异有统计学意义(P<0.05)。结论双歧三联活菌联合乳果糖治疗肝硬化肠源性内毒素血症可起显著降低血浆内毒素水平、改善肝功能的作用。
Objective To re se a rch th e c l in ic a l effect of b if id o b a c te r ia an d la ctulose in tre a tm en t of cirrh o sis enterogenous endotoxin. Methods 9 2 c a se s of p a t ien ts with cirrh o sis enterogenous endotoxin adm it ted and tre a ted in our h ospi tal from February 2014 to September 2016 were group selected as the research objects and randomly divided into two groups, the control group were treated with routine method, while the observation group were treated with bif idobacter ia and lactulose on the bas is of the control group, and the endotoxin, liver function and treatment effect before and af ter treatment were compared between the two groups. Results The toxin before an d af te r tre a tm en t in th e control group was re sp e c tiv e ly （0.41± 0.05）EU/mL and （0.29±0.06）EU/mL and （0.40±0.06）EU/mL and（0.17±0.04）EU/mL in the observation group, and the patients af ter treatment were improved compared with those before treatment, and the improvement range in the observation group was higher than that in the control group, and the difference had stat ist ical signif icance （P〈0.05） , and the AST, ALT and TBil af ter treatment in the observation group were bet ter than those in the control group, [（46.79±4.85）U/L, （46.69±5.12）U/L, （43.69±3.77）滋 mol/L vs （60.1 5±6.31 ） U/L,（55 .8 1±6 .4 5） U/L,（5 0 .5 6 ± 5 .2 3 ）μ mol/L], and th e differenc es had s ta t is t ic a l signifi- cance（P〈0.05）. Conclusion B if ido b ac ter ia an d la ctulose in tre a tm en t of cirrhosis enterogenous c an obviously re d u c e th e e n -dotoxin level and improve the liver function.
出处
《中外医疗》
2017年第3期120-121,125,共3页
China & Foreign Medical Treatment
