摘要
支气管哮喘是一种以可逆性气流受限为特征的气道慢性炎症性疾病。在支气管哮喘众多发病机制中,气道重塑与磷脂酰肌醇3激酶/蛋白激酶B(PI3K/PKB)通路联系紧密。气道重塑与支气管气道平滑肌细胞的增殖和凋亡密切相关。PI3K/PKB信号通路作为细胞内一条重要的信号传导通路,起到抑制细胞凋亡、促进细胞周期的进展,介导细胞增殖等作用,因而可以结合气道重塑与PI3K/PKB通路对支气管哮喘的发病和治疗进行探讨和研究。该研究现对支气管哮喘、气道重塑、PI3K/PKB通路的研究进展进行了综述,以期为支气管哮喘的治疗提供借鉴。
Bronchial asthma is a chronic airway inflammatory disease characterized by reversible airflow limitation.In the pathogenesis of bronchial asthma,airway remodeling is closely related to the PI3K/PKB pathway.And the airway remodeling is closely related to the proliferation and apoptosis of bronchial airway smooth muscle cells.As an important signal transduction pathway,PI3K/PKB signaling pathway plays an important role in inhibiting cell apoptosis,promoting cell cycle progression,mediating cell proliferation and so on.So it can be combined with airway remodeling and PI3K/PKB pathway for the exploration and study of the pathogenesis and treatment of bronchial asthma.This review focuses on advances in bronchial asthma,airway remodeling and PI3K/PKB pathway.
出处
《安徽医药》
CAS
2016年第12期2214-2218,共5页
Anhui Medical and Pharmaceutical Journal
基金
安徽省高等学校自然科学研究项目(KJ2015A124)
安徽省卫生计生委中医药科研课题(2016ZY03)
安徽中医药大学科研基金(2015qn020)
