摘要
目的对比曲马多与唑来磷酸钠用于多发性骨髓瘤治疗中对骨代谢的影响。方法随机选取该院于2012年12月—2016年10月收治的40例多发性骨髓瘤患者,按照治疗方法的区别命名为观察组(唑来磷酸钠)与对照组(曲马多)进行治疗,对比两组研究对象的治疗总有效率、血钙水平正常率、疼痛发生率、不良反应等临床指标。结果数据显示,观察组、对照组总有效率分别为85.00%、40.00%,相对于对照组来说,观察组总有效率更高(P<0.05);观察组、对照组血钙水平正常率分别为80.00%、40.00%,观察组血钙水平正常率明显较高(P<0.05);观察组、对照组0度疼痛发生率为分别为50.00%、10.00%,观察组无痛发生率明显较高(P<0.05);两组患者在治疗期间未发现影响治疗效果的不良反应。结论多发性骨髓瘤临床采用唑来磷酸钠进行治疗可获得较为理想的效果,安全性较高,对改善患者治疗预后、降低疼痛程度具有非常重要的意义。
Objective To compare the effect of tramadol and sodium zoledronic acid in treatment of patients with multiple myeloma on the bone metabolism. Methods Random selection 40 cases of patients with multiple myeloma admitted and treated in our hospital from December 2012 to October 2016 were selected and divided into two groups, the observation group adopted the sodium zoledronic acid, while the control group adopted the tramadol for treatment, and the total treatment effective rate, normal rate of blood calcium level, incidence rate of pains and adverse reactions were compared between the two groups. Results The data showed that the total effective rate in the observation group was higher than that in the control group(85.00% vs 40.00%)(P<0.05), and the normal rate of blood calcium level in the observation group was obviously higher than that in the control group(80.00% vs 40.00%)(P<0.05), and the incidence rate of painless in the observation group was obviously higher than that in the control group(50.00% vs 10.00%)(P<0.05), and there were no adverse reactions affecting the treatment effect during the treatment period in the two groups. Conclusion The effect of sodium zoledronic acid in treatment of patients with multiple myeloma is ideal, and the safety is high, which is of very important significance to improving the treatment prognosis of patients and reducing the pains degree.
作者
张家友
ZHANG Jia-you(Department of Hematology and Rheumatism, CNNC No. 416 Hospital, Chengdu, Sichuan Province, 610051 China)
出处
《中外医疗》
2017年第11期160-162,共3页
China & Foreign Medical Treatment
关键词
多发性骨髓瘤
唑来磷酸钠
治疗效果
Multiple myeloma
Sodium zoledronic acid
Treatment effect
