摘要
目的研究抗生素序贯疗法基础上应用转移因子治疗儿童急性下呼吸道感染疗效、症状改善时间及实验室指标观察。方法选取2014年2~10月接诊的儿童急性下呼吸道感染患者80例作为研究对象,将其进行随机分为对照组和研究组,每组40例。2组均进行常规检查与治疗,对照组患儿在此基础上进行抗生素序贯疗法,研究组患儿同时服用转移因子口服液,然后测定并比较2组患者症状缓解时间、住院时间、各测量指标、治疗后效果及不良反应发生情况等,并对其结果进行比较分析。结果经过治疗后,研究组患者的退热时间、咳嗽缓解时间及住院时间均明显少于对照组,差异有统计学意义(P<0.05);2组患者细胞免疫功能、CRP、PCT、WBC水平均发生明显的变化,且研究组患者的变化更加明显(P<0.05);除此之外,研究组患者的总有效率为95.0%,不良反应发生率为27.5%,均明显优于对照组,差异有统计学意义(P<0.05)。结论抗生素序贯疗法基础上应用转移因子治疗儿童急性下呼吸道感染,可以明显缩短症状改善时间及住院时间,降低不良反应的发生率,提高有效率,效果良好,具有临床应用价值,值得推广。
Objective To observe the therapeutic effects, the improving time of clinical symptoms and laboratory indexes of transfer factor on the basis of antibiotics sequential therapy in treatment of acute lower respiratory tract infection in children. Methods Eighty children patients with acute lower respiratory tract infection who were admitted and treated in our hospital from February 2014 to October 2014 were randomly divided into control group and observation group ,with 40 patients in each group. The patients in both groups underwent routine examination and treatment, and the patients in control group were treated by antibiotic sequential therapy,however,the patients in observation group,on the basis of control group,were treated by transfer factor oral liquid. Then the therapeutic effects, improving time of clinical symptoms, length of staying in hospital, laboratory indexes and incidence rate of adverse reactions were observed and compared between two groups. Results After treatment, the pyretolysis time, cough relief time and length of staying in hospital in observation group were significantly shorter than those in control group （ P 〈0.05） . After treatment the cellular immunity function,levels of CRP,PCT and WBC were significvantly changed in both groups,as compared with those before treatment,moreover,the changes in observation group were more obvious than those in control group （ P〈0.05） . Besides,the total effective rate was 95.0% in observation group,and incidence rate of adverse reactions was 27. 5% , which were suprior to those in control group （ P〈0.05） . Conclusion The transfer factor on the basis of antibiotics sequential therapy in treatment of acute lower respiratory tract infection in children can obviously shorten the improving time of clinical symptoms and length of staying in hospital, reduce the incidence rate of adverse reactions,improve efficiency,with good therapeutic effects, thus, which is worth using widely in clinical practice.
出处
《河北医药》
CAS
2017年第11期1627-1629,1633,共4页
Hebei Medical Journal
基金
湖北省自然科学基金资助项目(编号:2014FFB04510)
关键词
抗生素序贯疗法
转移因子
儿童急性下呼吸道感染
antibiotic sequential therapy
transfer factor
acute lower respiratory tract infection in children
