摘要
目的探讨传统统计法(Dixon检验法剔除离群值后计算和s)与稳健统计法[计算中位值和标准化四分位间距(NIQR)]医学检验实验室能力验证结果评价的适用范围。方法对2016年上海市临床检验中心快速C反应蛋白检测能力验证计划上报结果按检测系统分为A组(29家实验室)、B组(15家实验室)和C组(9家实验室)。应用传统统计法和稳健统计法分别对各组的统计量进行比较分析。结果对于A组结果,稳健统计法和传统统计法的指定值基本相同,但前者计算出的NIQR和指定值的标准不确定度(u_x)都小于后者计算出的s和指定值的u_x;对于B组结果,Dixon检验法剔除离群值后用传统统计法计算的指定值与稳健统计法计算所得较为接近,但前者所得到的u_x<0.3σ,而后者所得到的u_x>0.3σ;对于C组结果,Dixon检验法剔除离群值后用传统统计法计算的指定值与稳健统计法计算所得较为接近,2种方法计算所得的u_x>0.3σ,但前者计算所得的s均小于后者计算所得的NIQR。结论当实验室的数量较多(>18)时,可采用稳健统计法给出严格的评价结论;当利用Dixon检验法剔除离群值后,参加实验室的数量较少(12~18)的情况下,应对余下的数据采用传统统计法进行统计和分析;当剔除离群值后实验室的数量更少(≤12)时,除了对余下的数据采用传统统计法进行统计和分析,还需考虑指定值的u_x的影响。
Objective To investigate the scopes of conventional statistics（x and s after removal of outliers by Dixon method） and robust statistics [median and normalized interquartile range（NIQR）] for proficiency testing in laboratory medicine. Methodse Participants of the Proficiency Testing Program 2016 on C-reactive protein organized by Shanghai Center for Clinical Laboratory were classified into group A（29 laboratories）,group B（15 laboratories）and group C（9 laboratories）according to determination systems. The results of conventional statistics and robust statistics were analyzed and compared. Results As for group A,the designated values were same for the 2 methods. However,the NIQR and standard uncertainty （ux）of designated values by conventional statistics were smaller than s and ux by robust statistics. As for group B,the designated values were close between the 2 methods. Conventional statistics had ux〈0.3σ,and robust method had ux〉0.3σ. As for group C,the designated values were close between the 2 methods. Both methods had ux〉0.3σ. The s of conventional statistics was smaller than the NIQR of robust statistics. Conclusions When the number of participants is 〉18,robust statistics can be used. When the number of participants is 12-18,conventional statistics may be used. When the number is ≤12,besides conventional statistics should be used,the ux of designated values should be considered as well.
出处
《检验医学》
CAS
2017年第5期435-439,共5页
Laboratory Medicine
基金
基金项目:上海市第四轮公共卫生三年行动计划重点学科建设卫生检验学
