摘要
目的研究血必净联合血液灌流治疗急性重度有机磷农药中毒（AOPP）的临床效果.方法选取我院2013年8月至2016年8月收治的54例急性重度有机磷农药中毒患者为研究对象,随机将其分为对照组和观察组,每组27例.对照组给予洗胃、甘露醇注射、阿托品静滴等临床常规治疗,观察组在此基础上接受血必净联合血液灌流.比较两组患者临床指标及治疗前、后炎性细胞因子水平.结果观察组胆碱酯酶恢复正常时间、住院时间、阿托品总用量、氯磷定总用量等临床指标均明显优于对照组,差异显著（P〈0.05）;两组患者治疗后炎性细胞因子IL-6、IL-8、TNF-α水平均有下降,且观察组下降幅度优于对照组,差异显著（P〈0.05）.结论急性重度有机磷农药中毒患者接受血必净联合血液灌流治疗,可显著降低炎性因子水平,减少解毒药物用量,值得临床应用.
Objective To study the clinical effect of Xuebijing injection combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning （ AOPP）. Methods From August 2013 to 2016, 54 cases of patients with acute severe organophosphorus pesticide poisoning in our hospital were selected as research objects and randomly divided into control group and observation group, with 27 cases in each group. The patients in the control group were given gastric lavage mannitol injection, intravenous infusion of atropine and other clinical routine treatment, while the patients in the observation group were given Xuebijing injection combined with hemoperfusion. The clinical indicators and inflammatory cytokine levels of the two groups before and after treatment were compared. Results The cholinesterase recovery time, hospitalization time, total dosage of atropine, total dosage of pralidoxime chloride and clinical indicators of the observation group were significantly better than those of the control group, the differences were significant （P〈0.05）. After treatment, the inflammatory cytokines IL -8, IL - 6, and TNF -α levels were decreased, and the decrease of observation group was higher than that of the control group, the difference was significant （ P〈0.05）. Conclusion Xuebijing injection combined with hemoperfusion in the treatment of patients with acute severe organophosphorus pesticide poisoning can significantly reduce the levels of inflammatory factors, reduce detoxification drug dosage, which is worthy of clinical application.
出处
《临床研究》
2017年第4期106-107,共2页
Clinical Research
关键词
有机磷农药
中毒
血必净
血液灌流
organophosphorus pesticide
poisoning
Xuebijing injection
hemoperfusion
