摘要
目的:探讨不同分子亚型乳腺癌的MRI特征。材料与方法 :回顾性分析139例病人的术前乳腺MRI图像,包括强化方式、肿块样病灶强化后形态、边缘、内部强化特征、时间-信号强度曲线(TIC)类型、伴随征象。同时记录免疫组化指标ER、PR、HER-2的受体表达情况及Ki-67水平,按照乳腺癌分子亚型分类,分成Luminal A型、Luminal B型、HER-2阳性型和三阴性乳腺癌(TNBC)。以χ~2检验比较各分子亚型间MRI表现的差异,采用交叉列联表方法分析二者的相关性。结果:Luminal A型32例(23.0%),Luminal B型76例(54.7%),HER-2阳性型14例(10.1%),TNBC 17例(12.2%)。肿块样强化病变119例,非肿块样病变20例。肿块样强化病变中,病变的边缘与分子亚型呈低度相关(C=0.360,P=0.008),内部强化特征与分子亚型呈中度相关(C=0.442,P=0.001),TIC类型与分子亚型呈低度相关(C=0.318,P=0.019),而病灶的形态及伴随征象与分子亚型无相关性(C=0.065,P=0.791)。结论:不同分子亚型乳腺癌的MRI变现各异,分子亚型与部分MRI征象之间存在一定的相关性,通过术前MRI检查有助于初步判定预后及初步确定治疗方案。
Objective： To explore the MRI features of different molecular subtypes of breast cancer. Materials and Methods： Pre-operation breast MR images of 139 patients were retrospectively investigated concerning strengthen way, morphological, internal and marginal characteristics of mass like enhancement, time-signal intensity curve types and accompanied signs. Meanwhile, expression levels of immunohistochemistry indices including ER, PR, HER-2 and Ki-67 were recorded, and all subjects were assigned to different groups based on their molecular subtypes： Luminal A, Luminal B, HER-2 positive and TNBC. Differences in MRI characteristics were compared and tested with x-square test, relevance between MRI characters and molecular subtyping was analyzed by crosstab analysis. Results： N of each group： Luminal A（32）, Luminal B（76）, HER-2 posi- tive（14）, TNBC （17）. A total of 119 were mass like enhancement, whereas 20 were non-mass like enhancement. Among the mass like enhancement, the molecular subtype was slight correlated with margin （C=0.360, P=0.008） and time-signal intensity curve type （C=0.318, P=0.019）, moderately correlated with internal enhancement characteristics （C=0.442, P=0.001）, whereas morphology and accompanied signs were not relevant to molecular subtype（C=0.065, P=0.791）. Conclusions： Different subtypes of breast cancer showed distinct MRI manifestations, molecular subtyping was partially relevant to MRI characters. Thus, preoperation MRI is helpful in preliminary determination of prognosis and preliminary preparation of therapeutic plans.
出处
《中国临床医学影像杂志》
北大核心
2017年第5期327-330,共4页
Journal of China Clinic Medical Imaging
基金
吉林省科技厅自然科学基金项目(20140101170JC)
关键词
乳腺肿瘤
磁共振成像
Breast neoplasms
Magnetic resonance imaging
