摘要
微丸作为多单元给药制剂在临床应用中具有很多优点,而微丸型片剂更成为工业药剂学研究中的热点。微丸型片剂具有提高生物利用度、减少用药剂量和减轻不良反应等诸多优点。但包衣微丸受压后衣膜易破裂、压片过程中容易出现分层等因素限制了微丸压片技术的广泛应用。本文综述了包衣微丸压片的优势和难点,讨论了影响微丸压片的一些关键影响因素,包括丸芯、包衣膜材料、填充辅料和制备工艺等,并介绍了国内外有关微丸压片技术的研究进展,为推动微丸压片技术的工业化应用提供一些参考。
As a type of multiple unit dosage form, pellets has a lot of advantages in clinical application. Moreover, tablets containing pellets has been a hot area of research in industrial pharmaceutics. Some commercial products of tablets containing pellets are introduced in this paper. This kind of tablets has lots of advantages, such as improve the bioavailability, reduce the dosage and the risk of adverse drug reaction. However, the destruction of coating layer of the pellets during tableting and the segregation problem limit the wide application of tableting of coated pellets. This review summarizes the advantages and disadvantages of tablets containing pellets and discusses the key factors in tableting of coated pellets including the core of pellets, the coating materials, fillers and pharmaceutical technology. Furthermore, the progress of tableting of coated pellets and some useful information about application of this technology in industrial pharmaceutics are introduced, including new fillers, new approaches such as Wowtab and coating excipients into pellets. Those methods are very useful for solving segregation problem and protecting coated pellets.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2017年第5期631-637,共7页
Chinese Journal of Pharmaceuticals
关键词
多单元制剂
包衣微丸
微丸型片剂
压片
综述
multiple unit dosage form
coated pellet
tablet containing pellets
tableting
review
