摘要
钙化性主动脉瓣疾病（calcific aortic valve disease,CAVD）是心脏瓣膜疾病中最常见的一种.目前临床尚无有效的医疗手段预防CAVD或是逆转CAVD的发病过程.CAVD的发病机制尚无定论.CAVD一直被认为是年龄相关性疾病.过去几年人们对CAVD的发病原因和发病机制进行了大量研究并取得了快速进展.本文就CAVD发病机制的研究进展,包括脂质沉积、炎性反应、钙磷代谢、成骨化生以及相关的基本分子过程等方面进展进行综述.
Calcific aortic valve disease（CAVD） is the most common valvular disorder.There is no medical treatment to prevent and/or reverse the progression of CAVD and the etiology still requires further study.CAVD has long been described as a degenerative disease related to aging.In the past few years,our comprehension of the etiology and mechanisms leading to CAVD has progressed at a fast pace.In this article,we review the latest discoveries of CAVD,from aspects of lipid retention,inflammation,calcification,osteogenic transition and their basic molecular processes.
出处
《中华胸心血管外科杂志》
CSCD
2017年第3期188-192,共5页
Chinese Journal of Thoracic and Cardiovascular Surgery
