摘要
目的探讨甲基多巴联合拉贝洛尔治疗重度早发型子痫前期综合征的疗效及安全性。方法2叭1年3月—2014年9月本院共收治重度早发型子痫前期综合征患者82例,随机分成观察组和对照组,各41例。观察组给予甲基多巴及拉贝洛尔联合硫酸镁治疗;对照组给予硝苯地平联合硫酸镁治疗。观察两组治疗疗效、血流动力学指标及不良反应发生率。结果观察组显效率56.1%,总有效率97.6%,均高于对照组(31.7%、82.9%),差异有统计学意义;观察组心脏指数略高于对照组,但差异无统计学意义;观察组MAP,24h pro、TRP和S/D均显著低于对照组,差异有统计学意义;观察组不良反应总发生率为14.6%,显著低于对照组(34.2%),差异有统计学意义。结论甲基多巴及拉贝洛尔联合硫酸镁治疗重度早发型子痫前期综合征效果好,且能减少不良反应发生率,安全性高,值得推广。
Objective To analyze efficacy and safety of methyldopa and labetalol combined with magnesium sulfate in the treatment severe early onset preeclampsia syndrome.Methods From March 2011 to September 2014,a total of 82 patients were diagnosed with severe early onset preeclampsia syndrome in our hospital.These patients were randomly divided into observation group （41 cases） or control group （41 cases）.The observation group were given methyldopa and labetalol in combination with magnesium sulfate.Patients in the control group were treated with nifedipine combined with magnesium sulfate.The effect and safety were compared between the two groups.Results The observation group showed a rate of improvement of 56.10% （23 / 41） and a total effective rate of 97.56% （40 / 41）;both were higher than those of the control group [31.71% （13/41） and 82.93% （34/41）,respectively].Cardiac index was higher in the observation group than in the control group,but the difference was not statistically significant.MAP,24 h pro and Trp,and S / D were significantly lower in the observation group than in the control group.Adverse effects were noted in the observation group in 14.63%,significantly lower than 34.25% in the control group.Conclusion Methyldopa and labetalol were effective in the treatment of severe early onset preeclampsia syndrome with fewer adverse effects.
出处
《中国生育健康杂志》
2017年第3期237-239,共3页
Chinese Journal of Reproductive Health
