摘要
目的探讨川芎嗪在颅内动脉瘤介入围手术期中对预防和改善脑血管痉挛(CVS)的临床效果。方法 39例颅内动脉瘤破裂并蛛网膜下腔出血(SAH)患者随机分为川芎嗪组、尼莫地平组及空白对照组,每组13例。围手术期空白对照组患者不使用任何抗血管痉挛药物,尼莫地平组和川芎嗪组术前2 h开始分别给予尼莫地平和盐酸川芎嗪注射液,疗程均为2周,各组同时给予相应的护理措施。观察三组患者CVS的发生率。结果三组患者中空白对照组的CVS发生率为76.92%,明显高于川芎嗪组和尼莫地平组的15.38%和7.69%,差异有统计学意义(P<0.05)。而川芎嗪组和莫地平组的CVS发生率比较无明显差异(P>0.05)。结论川芎嗪可降低颅内动脉瘤破裂性蛛网膜下腔出血患者介入围手术期的CVS的发生率;针对性的护理可缓解患者的症状,改善预后。
Objective To discuss the clinical effects of ligustrazine in the prevention and treatment of cerebral vasospasm（CVS）in perioperative intracranial aneurysm intervention.Methods Thirty-nine patients of aneurysm rupture and subarachnoid hemorrhage were randomized into a ligustrazine group,a nimodipine group and a blank control group,13 cases in each one.In the perioperative stage,in the blank control group,no any anti-vasospasm drug was used.In the nimodipine group and the ligustrazine group,nimodipine and ligustrazine injection were given 2 h before operation respectively.The duration of treatment was 2 weeks.The corresponding nursing measures were applied in each group at the same time.The incidence of CVS was observed in the patients of the three groups.Results CVS incidence was 76.92% in the blank control group,higher apparently than 15.38% and 7.69% in the ligustrazine group and the nimodipine group separately,indicating the significant differences（P〈0.05）.CVS incidence was not different apparently between the ligustrazine group and the nimodipine group（P〉0.05）.Conclusion Ligustrazine reduces CVS incidence in the patients of subarachnoid hemorrhage in ruptured intracranial aneurysm in perioperative stage.The specific nursing measures relieve the symptoms and improve prognosis.
出处
《世界中西医结合杂志》
2017年第4期524-526,共3页
World Journal of Integrated Traditional and Western Medicine
基金
广东省中医药局科研课题基金资助项目(20161173)
关键词
颅内动脉瘤
蛛网膜下腔出血
川芎嗪
脑血管痉挛
Intracranial Aneurysm
Subarachnoid Hemorrhage
Ligustrazine
Cerebral Vasospasm
