摘要
目的观察健脾通络解毒法对急性冠状动脉综合征患者肾素—血管紧张素—醛固酮系统(RAAS)及微循环状态的影响情况。方法选取2014年2月至2015年7月收治的72例急性冠状动脉综合征患者为研究对象,将其随机分为对照组和观察组,各36例。对照组采用常规西医方法进行治疗,观察组则在对照组治疗的基础上,加用健脾通络解毒中药。观察两组患者治疗前后RAAS[包括血管紧张素Ⅱ(Ang-Ⅱ)、肾素(RA)及醛固酮(ALD)]及微循环状态相关指标[甲襞微循环加权积分(襻周积分、流态积分、形态积分)及其他指标(包括输出支管径、白微栓率、管襻数)]情况。结果治疗前两组患者的RAAS及微循环状态相关指标均无显著性差异(P>0.05),而治疗后10 d、20d及30 d观察组的RAAS相关指标均低于对照组,微循环状态相关指标则均优于对照组,两组比较差异有统计学意义(P<0.05)。结论健脾通络解毒法对急性冠状动脉综合征患者RAAS及微循环状态的影响更为积极,对患者疾病状态的综合改善效果更为突出。
Objective To observe the impacts jianpi tongluo jiedu therapy on RAAS and microcirculatory state in the patients with acute coronary syndrome. Methods From February 2014 to July 2015,72 patients of chronic coronary syndrome were collected as the subjects and were randomized into an controlled group and an observation group,36 cases in each one. In the control group,the conventional Western medicine was used. In the observation group,on the basis of the treatment as the control group,the herbal medicine for strengthening spleen,promoting collateral circulation and detoxification（ jianpi tongluo jiedu therapy）was added. RAAS（ including Ang-Ⅱ,RA and ALD）,the indicators of microcirculatory state[weighting integral of nailfold microcirculation（ loop week integral,flow integral,form integral） and the others（ output capillary diameter,the shear rate of veinules,capillary loop numbers） were observed before and after treatment in the patients of the two groups]. Results Before the treatment,RAAS and microcirculatory indicators were not different significantly between the two groups（ P 〉0. 05）. The relevant indicators of RAAS in the observation group were lower than those in the control group and the microcirculatory indicators were better than those in the control group in 10 d,20 d and 30 d after treatment,indicating the the significant differences in comparison（ P〈 0. 05）. Conclusion Jianpi tongluo jiedu therapy is proactive in the impacts on RAAS and microcirculatory state in the patients of acute coronary syndrome and achieves the superior effects on the comprehensive improvements in the conditions of patients.
出处
《世界中西医结合杂志》
2017年第4期544-546,共3页
World Journal of Integrated Traditional and Western Medicine
