摘要
部分肝切除术是治疗各种肝脏肿瘤的有效方法,而肝再生功能障碍则是其严重并发症之一.因此,部分肝切除术后肝再生（LR）能力显得尤为重要.本文从细胞因子、生长因子、代谢和信号通路等方面对肝再生的分子机制进行综述,并介绍近年来中药促进肝再生的研究进展,以进一步明确肝再生发生发展的分子机制,为治疗肝再生障碍类疾病的药物研发提供有价值的研究信息.
Partial hepatectomy （PH） is an effective method for the treatment of various liver tumors,and liver regeneration dysfunction is one of the most serious complications.Therefore,liver regeneration （LR） after PH is particularly important.In this paper,we reviewed the molecular mechanisms of LR including cellular factors,growth factors,metabolism and related signaling pathways,and reviewed the research progresses of the traditional Chinese medicine （TCM） in promoting liver regeneration.The aim was to further clarify the mechanism of the occurrence and development of LR,and to provide valuable information for the development of drugs for treating liver regeneration disorders.
出处
《中华肝胆外科杂志》
CSCD
北大核心
2017年第5期357-360,共4页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金（81274195）
关键词
肝再生
分子机制
肝细胞增殖
中药
Liver regeneration
Molecular mechanisms
Hepatocyte proliferation
Chinese herbs
