摘要
人体肠道微生态是一个复杂的系统,由数量庞大、结构复杂的微生物群落组成,与人类健康和疾病紧密相关。各类肠道微生物相互影响,共同维持肠道正常结构与消化、吸收、代谢等功能。近年来大量研究表明肠道微生态失调在结直肠癌发生发展过程中发挥着重要的作用,而微生态制剂通过调节微生态平衡可达到预防和辅助治疗结直肠癌的目的。本文对肠道微生态与结直肠癌的早期筛查、发病关系及微生态制剂参与结直肠癌的防治作用进行综述,以求为该病的诊断、预防和治疗等提供一些新思路。
Human gut microbiota is a complex microecological system, which is constituted by a large number of complex microbial communities and is closely related to human health and diseases. All kinds of microbes, interacting with each other, maintain the normal structure and functions of gut together such as intestinal digestion, absorption, metabolism of nutrients. Recently, muhiple studies have showed that the gut microbiota plays an important role involved in the occurrence and development of colorectal cancer. In contrast, microecologics can be used for the prevention and adjuvant treatment of eoloreetal cancer by regulating the balance of gut microbiota. Here, this review elaborates the latest research progress on the relationship between gut microbiota and colorectal cancer and on the functions of the microecologies for screening, prevention and treatment of colorectal cancer, so as to highlight a potential diagnosis, prevention and therapeutic use of microbiota in patients with colorectal cancer.
出处
《循证医学》
CSCD
2017年第2期120-124,共5页
The Journal of Evidence-Based Medicine
基金
国家高技术研究发展计划资助项目(2015AA020701)
解放军医学院&解放军总医院博士创新基金资助项目(B14013)
