摘要
目的分析血浆滤过透析(PDF)治疗重型肝炎的不良反应发生情况,探讨PDF治疗重型肝炎过程中不良反应的防治方法。方法选择2016年1月1日~12月31日期间江西省南昌市第九医院住院的重型肝炎患者209例,均予PDF治疗,治疗465例次。观察并记录PDF治疗过程中不良反应。分析不良反应发生的原因,并制定防治措施。结果 PDF治疗过程中,患者发生不良反应86例次(18.49%),其中发生率较高的为血压下降31例次(6.67%)和皮肤瘙痒皮疹25例次(5.38%),其次腹痛恶心呕吐8例次(1.72%)、畏寒寒战7例次(1.51%)、面部口唇舌尖麻木6例次(1.29%)、穿刺处皮下血肿3例次(0.65%)、三腔管堵塞2例次(0.43%),还有血压升高、低血糖、心率减慢、血氧饱和度下降各1例次。通过及时处理,上述不良反应均恢复正常,对人工肝治疗的继续进行没有影响,患者均能顺利完成治疗。结论 PDF治疗重型肝炎中发生的不良反应是可以积极预防和及时处理的,在PDF治疗过程中加强对患者的观察和不良反应的处理,对保证人工肝PDF治疗顺利进行、提高治疗有效率、降低不良反应的发生率具有重要意义。
Objective To analyze the incidence of adverse reactions in the treatment of severe hepatitis with plasma filtration dialysis（PDF）, and to explore the prevention and treatment of adverse reactions in the treatment of severe hepatitis with PDF. Methods 209 patients with severe hepatitis who were hospitalized in the Ninth Hospital of Nanchang City in Jiangxi Province from January 1, to December 31, 2016 were studied. The patients were treated with PDF treatment of 465 times. The adverse reactions during the course of PDF treatment were observed and recorded. The causes of adverse reactions were analyzed, and the preventive measures were formulated. Results In the course of PDF treatment, there were 86 cases（18.49%） of patients with adverse reactions. The relatively high incidences were those of blood pressure drop with 31 cases （6.67%） and skin itching rash with 25 cases（5.38%）, respectively, followed by 8 cases （1.72%） of abdominal pain, nausea and vomiting, 7 cases （1.51%） of chilis, 6 cases （1.29%） of facial lips numbness, 3 cases（0.65%） of the subcutaneous hematoma, 2 cases （0.43%） of three-lumen blockage. There was 1 case of high blood pressure, low blood sugar, slow heart rate and blood oxygen saturation decrease, respectively. Through timely treatment, the above-mentioned adverse reactions were back to normal, and the treatment had no effect on the continuous treatment of artificial liver. The patient could successfully complete the treatment. Conclusion The adverse reactions of PDF treatment in severe hepatitis can be actively prevented and timely treated. In the course of PDF treatment, strengthening the observation of patients and the treatment of adverse reactions has great significance in ensuring the smooth progress of artificial liver PDF treatment, improving the efficiency of treatment and reducing the adverse reac- tions.
出处
《中国现代医生》
2017年第13期1-3,共3页
China Modern Doctor
基金
江西省南昌市科技局立项课题(洪科发计字【2016】96号)
关键词
血浆滤过透析
重型肝炎
不良反应
处理
Plasma filtration dialysis
Severe hepatitis
Adverse reactions
Treatment
