摘要
目的:探讨灯盏细辛注射液对急性脑梗死患者血清HIF-1α、Caspase-3及血尿酸水平的影响。方法:选取本院神经内科住院治疗的急性脑梗死患者86例,患者或家属签字同意,按随机数字表法进行分组,对照组43例采用常规治疗,观察组43例在常规治疗上给予灯盏细辛注射液治疗,治疗前后采血测定血液流变学、炎症因子及血清HIF-1α、Caspase-3、血尿酸水平,同时对比临床疗效及不良反应。结果:对照组治疗有效率81.40%低于观察组治疗有效率95.35%,具有统计学意义(P<0.05);观察组治疗后血液黏度指标及红细胞压积均低于对照组,治疗后血清Hcy、Hscrp、TNF-α及IL-1水平低于对照组,治疗后血清HIF-1α、Caspase-3浓度及血尿酸水平显著低于对照组,具有统计学意义(P<0.05)。结论:采用灯盏细辛注射液有效降低急性脑梗死患者血清HIF-1α、Caspase-3及血尿酸水平,安全性高,效果显著。
Objective ： To investigate the effect of serum HIF - 1α, Caspase - 3 and blood uric acid by lamps asarum injection in patients with acute cerebral infarction. Methods ： A total of 86 patients with acute cerebral infarction from our hospital neurology were collected and randomly divided into the control group and the experimental group with 43 cases in each group. Patients in the control group were treated by routine therapy and patients in the experimental group were treated on the base of routine therapy with lamp asarum injection. We measured the blood hemorheology, inflammatory factors and serum HIF - 1α, Caspase - 3 and blood uric acid levels before and after treatment and compared the clinical curative effect and adverse reactions. Results ： The con- trol group＇s treatment effective rate 81.40% was lower than the experimental group＇s effective rate 95.35% with statistical significance （P 〈 0. 05 ）. The experimental group＇s blood viscosity index and bematokrit were lower than the control group＇s after treat- ment. The serum Hcy, Hs -crp,TNF-α and IL- 1 levels were lower than the control group＇s after treatment. The serum HIF - Ict, Caspase- 3 concentration and blood uric acid levels were significantly lower than the control group＇s with statistical significance （ P 〈 0. 05 ）. Conclusion ： Lamps asarum injection in the treatment of the patients with acute cerebral infarction can effectively reduce the serum HIF - 1 α, Caspase - 3 and blood uric acid levels with high safety. The effect is remarkable.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第5期996-998,共3页
Liaoning Journal of Traditional Chinese Medicine
