摘要
WT1基因位于人类染色体11p13,分子量约50kb,编码产物为转录调节因子,与Wilms瘤的形成密切相关,它的突变与AML的未成熟表型有关[1]。笔者就WT1在造血系统肿瘤中的表达、表达调控、靶基因及临床应用价值的研究进行综述。现报告如下。
Summary Wilms tumor gene 1 （WT1） manifests both tumour suppressor and oncogenic activities,and WT1 can either activate or repress numerous target genes resulting in disparate biological effects. There are many re- searchs of WT1 gene in growth, development and tumor,in recent years WT1 gene on hematopoietic neoplasias re- search attracted the attention of people and some of the research results have been used in clinical work. This paper reviews the expression regulation,target genes and clinical application value study of WT1.
出处
《临床血液学杂志》
CAS
2017年第3期395-398,共4页
Journal of Clinical Hematology
基金
江西省卫生计生委项目(No:20175381)
关键词
WT1基因
造血调控
微小残留病
白血病
靶向治疗
WT1 gene
hematopoietic regulation
minimal residual disease
leukemia
targeted therapy
