摘要
目的:探讨小儿哮喘合并呼吸道病毒感染对气道重塑、炎症反应程度的影响。方法:收集在本院接受治疗的哮喘合并呼吸道病毒感染小儿41例作为观察组,另取同期入院治疗的单纯哮喘小儿50例作为对照组。采用高分辨率CT测定两组右上叶尖段(RB1)、左下叶后基底段(LB10)气道重塑参数,测定血清气道重塑指标、炎症因子含量。结果:观察组RB1、LB10的LA、WA、TA水平均显著低于对照组,血清中气道重塑指标TGF-β1、Smad3、PⅠNP、PⅢNP的含量均高于对照组,血清中炎症指标IL-4、IL-5、TNF-α的含量均高于对照组(P<0.05)。结论:合并呼吸道病毒感染可加重哮喘患儿气道重塑及全身炎症反应。
Objective： To study the effect of pediatric asthma complicated by respiratory virus infection on airway remodeling and inflammation. Methods： A total of 41 children with asthma complicated by respiratory virus infection who were treated in our hospital between May 2012 and March 2016 were collected as observation group, and 50 children with asthma alone who were treated in our hospital during the same period were selected as control group. High-resolution CT was used to determine the right upper lobe apical segment （RB1） and the left lower lobe posterior basal segment （LB10） airway remodeling parameters of two groups of patients, and serum airway remodeling index and inflammatory factor contents were detected. Resuits： LA, WA and TA levels of RB1 and LB10 of observation group were significantly lower than those of control group, serum airway remodeling indexes TGF-β1, Smad3, P Ⅰ NP and PⅢ NP contents were significantly higher than those of control group, serum inflammation indexes IL-4, IL-5 and TNF-α contents were significantly higher than those of control group （P 〈0.05）. Conclusions： Complication of respiratory virus infection can aggravate the airway remodeling and systemic inflammation in children with asthma.
出处
《海南医学院学报》
CAS
2017年第8期1085-1087,1091,共4页
Journal of Hainan Medical University
基金
湖北省科技计划项目面上基金(2015CFB649)~~
关键词
支气管哮喘
呼吸道病毒
气道重塑
炎症反应
Bronchial asthma
Respiratory virus
Airway remodeling
Inflammation
