期刊文献+

血小板功能检测指导的个体化抗血小板治疗在冠心病患者中的临床应用 被引量:1

The clinical utility of personalization of antiplatelet therapy tailored by platelet function testing in patients with coronary artery disease
下载PDF
导出
摘要 维持适当的血小板活性对经皮冠状动脉介入术(PCI)后患者预后意义重大,血小板活性过高易导致缺血事件,相反则易导致出血事件.最常见的双联抗血小板方案由阿司匹林及二磷酸腺苷(ADP)受体拮抗剂组成.氯吡格雷是使用最广泛的ADP受体拮抗剂,其抗血小板作用与CYP2C 19基因型密切相关.
出处 《中国心血管病研究》 CAS 2017年第5期389-393,I0001,共6页 Chinese Journal of Cardiovascular Research
基金 上海市胸科医院科技发展基金资助项目(项目编号:2014YZDH20201)
关键词 冠状动脉疾病 血小板功能检测 个体化治疗 Coronary artery disease Platelet function testing Personalized therapy
  • 相关文献

参考文献5

二级参考文献65

  • 1Navarese EP, Verdoia M, Schaffer A, et al. Ischaemic and bleeding complications with new, compared to standard, ADP- antagonist regimens in acute coronary syndromes: a meta-analy- sis of randomized trials. QJM, 2011,104 : 561-569.
  • 2Frelinger AL 3rd, Michelson AD, Wiviott SD, et al. Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasug- rel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. Thromb Haemost, 2011,106 : 219-226.
  • 3Jung JH, Min PK, Lee SH, et al. Clopidogrel pretreatment be- fore primary percutaneous coronary stenting in patients with acute ST-segment elevation myocardial infarction: comparison of high loading dose (600 rag) versus low loading dose (300 mg). Coron Artery Dis, 2009,20 : 150-154.
  • 4Levine GN, Bates ERr Blankenship JC, et al. 2011 ACCF/AHA/ SCAI Guideline for Percutaneous Coronary Intervention: executive summary: a report of the American College of Cardiology Foun- dation/American Heart Association Task Force on Practice Guide- lines and the Society for Cardiovascular Angiography and Inter- ventions. Catheter Cardiovasc Interv, 2012,79 : 453-495.
  • 5Wijns W, Kolh P, Danchin N, et al. Guidelines on myocardial revascularization. Eur Heart J, 2010,31 : 2501-2555.
  • 6Price M J, Berger PB, Teirstein PS, et al. Standard- vs high- dose clopidogrel based on platelet function testing after percuta- neous coronary intervention: the GRAVITAS randomized trial. JAMA, 2011,305 : 1097-1105.
  • 7Bonello L, Berbis J, Laine M, et al. Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarc- tion. Thromb I-Iaemost, 2012,108 : 101-106.
  • 8Mehta SR, YusufS, Peters R J, Bertrand ME, Lewis BS, Natarajan MK, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study. Lancet 2001,358:527-33.
  • 9Steinhubl SR, Berger PB, Mann JT 3rd, Fry ET, DeLago A, Wilmer C, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. JAMA 2002,288:2411-20.
  • 10Matetzky S, Shenkman B, Guetta V, Shechter M, Beinart R, Goldenberg 1, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004,109:3171-5.

共引文献64

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部