摘要
原发性干燥综合征是一种主要累及外分泌腺的自身免疫性疾病,也常伴有肌肉骨骼、神经系统、肺、肾、血液系统等多系统损伤。其临床表现多样,表达谱宽,治疗取决于病情轻重及器官累及情况。局部外分泌腺干燥症可加强患者教育、改善环境、使用局部药物等,严重器官受累需糖皮质激素和(或)免疫抑制剂等治疗。近年来,生物制剂治疗难治及复发患者取得了初步疗效,但仍需大样本随机对照试验研究确定长期有效性。
Primary Sjogren＇s syndrome （pSS） is a progressive autoimmune disease characterized by sicca and systemic manifestations. Treatment decisions are based on the evaluation of symptoms and extraglandular manifestations. Sicca is managed by education, environment modification, artificial tears, secretagogues and treatments for complications. Severe and acute systemic manifestations are managed with glucocorticoids and/or immunosuppressant drugs. The role for biologic agents is promising, but no double-blind randomized controlled trials proving the efficacy of these drugs are available.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2017年第6期477-479,共3页
Chinese Journal of Practical Internal Medicine
