摘要
目的探讨短暂性脑缺血发作患者行阿托伐他汀钙治疗对颈动脉粥样硬化斑块和血脂的影响。方法选取2014年3月~2015年10月我院收治的250例伴有颈动脉粥样硬化斑块的短暂性脑缺血发作患者为研究对象,根据治疗方法的不同分为观察组(150例)和对照组(100例)。两组均给予阿司匹林治疗,在此基础上对照组给予辛伐他汀治疗,观察组给予阿托伐他汀钙治疗。两组患者在治疗前后均行颈动脉超声检查,以观察颈动脉粥样硬化斑块面积与内膜中层厚度,对血脂水平的变化进行检测,并比较两组脑血管事件的发生率。结果与治疗前比较,观察组治疗后颈动脉斑块面积与内膜中层厚度均明显减小,血清TG、TC、LDL水平明显降低,HDL水平上升(P<0.05),而对照组治疗后颈动脉斑块面积与内膜中层厚度改变不太明显,且血脂水平无显著改善;观察组脑血管疾病发生率为4.67%,低于对照组的19.00%(P<0.05)。结论阿托伐他汀不但具有调节血脂水平的作用,而且可减少或消除短暂性缺血发作患者的颈动脉粥样硬化斑块,值得临床推广应用。
Objective To explore influences of atorvastatin calcium on carotid atherosclerotic plaque and blood lipid of patients with transient ischemic attack. Methods 250 patients with transient ischemic attack accompanied by carotid atherosclerotic plaque who were admitted to our hospital from March 2013 to October 2015 were selected as research objects.They were divided into the observation group（150 cases） and the control group（100 cases） according to different treatment methods and they were all given aspirin for treatment.The control group was treated by simvastatin at the basis of it while the observation group was treated by atorvastatin calcium.Patients in two groups were all received carotid ultrasound examination to observe the carotid atherosclerotic plaque area and intima- media thickness,to test the changes of blood lipid levels and to compare the incidences of cerebrovascular events. Results In the observation group,the carotid artezT plaque area and intima-media thickness after treatment were both significantly decreased when compared with those before treatment.In addition,triglyceride（TG）,total cholesterol（TC） and low density lipoprotein（LDL） levels of serum were significantly lower and high density lipoprotein（HDL） level was increased（P 〈 O.05）.While in the control group,the carotid artery plaque area and intima-media thickness after treatment were not significantly changed.And blood lipid level was not significantly improved.The incidence of cerebrovascular disease of the observation group was 4.67%,lower than that of patients in the control group （P 〈 0.05）. Conclusion Atorvastatin can not only regulate the level of blood lipid but also reduce or eliminate carotid atherosclerotic plaque of patients with transient ischemic attack,which is worthy of clinical application.
出处
《中国医药科学》
2017年第7期52-55,共4页
China Medicine And Pharmacy
