摘要
目的观察评价氯环利嗪片联合荨麻疹丸治疗慢性荨麻疹(CU)的临床效果与安全性,为CU的治疗提供科学的依据。方法选择2014年2月~2016年6月期间我院收治的慢性荨麻疹患者122例,按照数字表法随机分为两组,对照组61例给予氯环利嗪片治疗;观察组61例则在对照组基础上加用荨麻疹丸治疗,并比较两组的临床效果。结果治疗4周后,观察组总有效率为96.72%则显著地高于对照组的73.77%(χ~2=12.7735,P<0.05),治疗前,两组IgE水平(P>0.05),治疗4周后,观察组与对照组IgE水平均明显的低于治疗前(t=-28.1701、-14.9296,P<0.05),而治疗后观察组IgE水平则显著地低于对照组(t=-24.5631,P<0.05),观察组IL-10水平则明显的低于对照组(t=-2.8837,P<0.05),观察组IL-18水平则显著地高于对照组(t=8.7930,P<0.05),观察组临床痊愈中复发率为12.24%而显著地低于对照组46.88%(χ~2=12.0884,P<0.05)。结论氯环利嗪片联合荨麻疹丸治疗慢性荨麻疹(CU),能够显著地提高疗效,充分发挥了中西医结合的特点,达到了优势互补,能够大大的改善临床症状,有效的降低了复发率,不良反应少,安全性好,值得临床大力推广应用。
Objective To observe the clinical effect and safety of chloroeycline tablets combined with urticaria pills in the treatment of chronic urticaria （CU） and to provide scientific reference for the treatment of CU. Methods 122 patients with chronic urticaria who were admitted to our hospital from February 2014 to June 2016 were selected and they were randomly divided into two groups according to the random number table method.61 patients in the control group were treated with chlorcyclizine tablets while 61 patients in the observation group were treated by urticaria pills at basis of control group.Clinical effects of two groups were compared. Results After 4 weeks of treatment,total effective rate of the observation group was 96.72%,significantly higher than that of the control group 73.77%（Z2=12.7735,P 〈 0.05）.Before treatment,lgE levels in the two groups（P〉0.05）.After 4 weeks of treatment,IgE levels of the observation group and the control group were both significantly lower than those before treatment （t=- 28.1701,-14.9296,P 〈 0.05） while IgE level of the observation group was significantly lower than that of the control group（t=-24.5631;P〈0.05）.IL-10 level of the observation group was significantly lower than that of the control group （t=-2.8837, P 〈 0.05） while IL-18 level of the observation group was significantly higher than that of the control group（t=8.7930,P 〈 0.05）.The recurrence rate in the clinical recovery of the observation group was 12.24%,significantly lower than that of the control group 46.88%0（2=12.0884,P 〈 0.05）. Conclusion Chlorocycline tablets combined with urticaria pills in treatment of chronic urticaria （CU） can significantly improve the curative effect,give full play to the characteristics of integrated traditional Chinese and Western medicine,greatly improve clinical symptoms and effectively reduce the recurrence rate.It has few adverse reactions and good security,worthy of clinical promotion and application.
出处
《中国医药科学》
2017年第7期62-65,共4页
China Medicine And Pharmacy
