摘要
目的:评价血清胱抑素C(Cys-C)水平对于糖尿病病人肾功能不全的临床检测意义。方法:选取225例糖尿病病人,记录性别、年龄、病程、血压、身高及体质量,计算出体质量指数(BMI),使用肾动态显像法测定肾小球滤过率(GFR)(mL·min^(-1)·1.73 m^(-2))值。所有病人分为3组:A组(GFR<60)、B组(60≤GFR<90)、C组(GFR≥90)。检测血清胱抑素C(Cys-C)、血清视黄醇结合蛋白(RBP)、血肌酐(Scr)、血尿素(Sur)、血尿酸(UA)、24 h尿微量白蛋白(UmAlb)。结果:3组病人年龄、病程、Scr、Sur、UA、RBP、Cys-C和UmAlb差异均有统计学意义(P<0.05);3组病人年龄、病程、Scr、Sur、UA、RBP、Cys-C、UmAlb与GFR均呈负相关关系(P<0.01);多元逐步回归显示Cys-C、年龄、UmAlb进入最佳方程,且血清Cys-C最先进入。结论:Cys-C、年龄、UmAlb是影响糖尿病病人GFR的主要因素,其中血清Cys-C是反映早期肾功能受损的一个更为理想、敏感的常规指标,有助于糖尿病肾脏疾病的早期防治。
Objective： To evaluate the clinical significance of serum cystatin C （Cys-C） level in patients with diabetes mellitus complicated with renal disfunction. Methods：The gender, age, course of disease, blood pressure, height and quality of 225 patients with diabetes mellitus were recorded,the body mass index（BMI） was calculated, and glomerular filtration rate（GFR） （mL·min^-1·1.73 m^-2） was detected using Kidney dynamic imaging. All patients were divided into the group A （GFR 〈 60）, group B （60 ≤ GFR 〈 90） and group C （GFR ≥90）. The levels of serum Cys-C, serum retinol binding protein （RBP）, serum creatinine （Scr）, blood urea （Sur）, blood uric acid （UA）,24 hour urine microalbumin （UmAlb） in three groups were detected. Results：The differences of the age, course of disease, and the levels of Scr, Sur, UA, RBP, Cys-C and UmAlb between three groups were statistically significant（ P 〈 0. 05 ）. The age, course of disease,and the levels of Scr, Sur, UA, RBP, Cys-C and UmAlb were negative correlation with GFR in three groups（P 〈 0.01 ）. The multiple stepwise regression analysis showed that the Cys-C, age, umalb entered the best equation, and serum Cys-C was the first. Conclusions： The Cys-C, age, UmAlb are the main influencing factors of GFR in patients with diabetes mellitus. The serum Cys-C is more ideal and sensitive conventional index in reflecting the early renal disfunction, which can help the early prevention and treatment of diabetic renal disease.
作者
王丽
毕娅欣
金国玺
裴晓艳
WANG Li BI Ya-xin JIN Guo-xi PEI Xiao-yan(Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, Chin)
出处
《蚌埠医学院学报》
CAS
2017年第3期293-296,共4页
Journal of Bengbu Medical College
基金
安徽省卫生厅医学科研课题(2009A04)
