摘要
随着现代交通的发展,脊髓损伤（spinal cord injury,SCI）已经成为常见的外伤性疾病,可导致中枢神经系统感觉运动功能障碍且不可逆[1-2],造成截瘫或四肢瘫,从而严重影响患者的日常生活和生存质量。其并发症的发生也会是致命的威胁并大大加重患者的家庭负担,例如膀胱和直肠功能障碍、心血管系统和呼吸系统功能障碍[2-3]。
The incidence of spinal cord injury is very high, which often brings disastrous consequences to the patients and their families. And there is no ideal treatment. In recent years, with the in-depth study on molecular biology and genetic engineering technology, cell transplantation as the biotherapy strategy and treatment for spinal cord injury has been developed. Schwann cells have become the focus of research because of their obvious advantages for nerve repair. Schwann cells are easy to obtain and culture, and can reduce the immune rejection after autologous transplantation, which lead to no ethical restrictions. Schwann cells transplanted into the damaged spinal cord can swallow necrotic tissues, reduce tissue defects and secrete neurotrophic factors, adhesion molecules and extracellular matrices, which can promote the growth of axons and myelins, and further improve the sensory and motor function. However, due to the bad local micro environment, the promotion of axonal growth and remyelination is limited by the transplantation of only Schwann cells into the spinal cord. Therefore, the researchers have used Schwann cells with other cells / molecules and the technological transformation of genetic engineering has been realized. And furthermore, a rapid development has been achieved in the treatment of spinal cord injury, as well as the clinical application of Schwann cells. This review made a summary on the research of Scbwann cell transplantation.
作者
钱隆
张小雷
黄亮节
刘彦
唐家广
QIAN Long ZHANG Xiao-lei HUANG Liang-jie LIU Yan TANG Jia-guang(Training Base for Graduate Students, Jinzhou Medical University, the first Affiliated Hospital of PLA General Hospital, Beijing, 100048, China)
出处
《中国骨与关节杂志》
CAS
2017年第5期357-361,共5页
Chinese Journal of Bone and Joint
关键词
施万细胞
细胞移植
脊髓损伤
干细胞
遗传工程
Schwann cells
Cell transplantation
Spinal cord injuries
Stem cells
Genetic engineering
