摘要
目的探讨英夫利昔单抗治疗溃疡性结肠炎的效果及对炎症因子水平的影响。方法选取2013年7月~2015年10月在中国医科大学附属盛京医院就诊的中度溃疡性结肠炎患者240例,将其随机分为观察组和对照组,每组120例。对照组给予常规药物硫唑嘌呤进行治疗,观察组在此基础上给予英夫利昔单抗,连续治疗30 d。观察两组临床疗效,比较两组治疗前后血清C反应蛋白(CRP)、红细胞沉降率(ESR)、白蛋白(Alb)、血红蛋白(Hb),以及炎症因子水平。结果观察组总有效率(80.83%)显著高于对照组(61.67%),差异有统计学意义(P<0.05)。两组治疗后CRP、ESR、Alb、Hb均较治疗前明显改善,差异有统计学意义(P<0.05),且观察组治疗后CRP、ESR水平显著低于对照组,Alb、Hb水平显著高于对照组,差异有统计学意义(P<0.05)。两组治疗后白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-23(IL-23)、肿瘤坏死因子-α(TNF-α)水平均较治疗前显著下降,差异有统计学意义(P<0.05),且观察组治疗后IL-6、IL-8、IL-23、TNF-α水平均显著低于对照组,差异有统计学意义(P<0.05)。结论英夫利昔单抗治疗溃疡性结肠炎效果确切,其可有效改善患者的肠道黏膜状态,同时对降低炎症因子水平有重要意义,有利于患者预后恢复,值得临床推广应用。
Objective To investigate the effects of Infliximab in the treatment of ulcerative colitis and its influence on the levels of inflammatory factors. Methods Two hundred and forty patients with moderate ulcerative colitis treated in Shengjing Hospital Affiliated to China Medical University from July 2013 to October 2015 were selected and randomly divided into observation group and control group, with 120 cases in each group. The control group was given routine drug Azathioprine, on basis of which, the observation group was added with Infliximab, continuous treatment for 30 d. The clinical efficacy of the two groups was observed, and the levels of serum C-reactive protein （CRP）, erythrocyte sed- imentation rate （ESR）, albumin （Alb） hemoglobin （Hb） and inflammatory factors beforel and after treatment between the two groups were compared. Results The total effective rate of observation group （80.83%） was significantly higher than that of the control group （61.67%）, the difference was statistically significant （P 〈 0.05）. After treatment, the levels of CRP, ESR, Alb, Hb in the two groups were all improved compared with those before treatment, the differences were all statistically significant （P 〈 0.05）, and the levels of CRP and ESR in the observation group were lower than those of the control group, while the levels of Alb and Hb were higher than those of the control group, the differences were all sta- tistically significant （P 〈 0.05）. The levels of interleukin-6 （IL-6）, interleukin-8 （IL-8）, interleukin-23 （IL-23） and tumor necrosis factor alpha （TNF-ot） in the two groups after treatment were all significantly lower than those before treat- ment, the differences were statistically significant （P 〈 0.05）, and the levels of＇IL-6, IL-8, IL-23 and TNF-ot in the ob- servation group after treatment were lower than those of control group, there were statistically significant differences （P 〈 0.05）. Conclusion Infliximab in the treatment of severe ulcerative colitis has exact effects, which can effectively im- prove the patient＇s intestinal mucosa, and it has important significance for decreasing the level of inflammatory factors,it is conducive for the prognosis of patients and worthy of clinical promotion and application.
作者
杨俊
金玉
潘迪
王东旭
林艳
郑长青
YANG Jun JIN Yu PAN Di WANG Dongxu LIN Yan ZHENG Changqing(The Second Department of Gastroenterology, Shengjing Hospital Affiliated to China Medical University, Liaoning Province, Shenyang 117004, China)
出处
《中国医药导报》
CAS
2017年第15期148-151,共4页
China Medical Herald
基金
辽宁省科技厅科学技术计划项目(2013225303)
