摘要
目的观察痰热清注射液辅助治疗对脓毒症患者病情的改善情况和死亡率的干预作用。方法选取2013年5月~2016年5月来我院进行治疗的脓毒症患者90例,按照随机数字表法将90例患者分为观察组和对照组,每组各45例。对照组采用西医常规治疗,观察组则在西医常规治疗的基础上辅以痰热清注射液,治疗7 d后,观察炎症相关指标的变化,包括C反应蛋白(CRP)、血液降钙素原(PCT)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α);记录治疗前后急性生理学及慢性健康状况Ⅱ(APACHEⅡ)评分;治疗21 d后,统计疗效和死亡率;统计治疗过程中出现的不良反应并发率。结果治疗7 d后观察组的CRP、PCT、IL-6、IL-8、TNF-a改善效果优于对照组,且差异有统计学意义(P<0.05);观察组的APACHEⅡ评分低于对照组(P<0.05);治疗21 d后,观察组的显效率(44.4%)高于对照组的(28.9%),差异有统计学意义(P<0.05)。在死亡率方面,两组的差异无统计学意义(P>0.05)。观察组休克、深静脉血栓的发生率均低于对照组,差异有统计学意义(P<0.05)。结论痰热清注射液在降低脓毒症患者炎症反应、改善临床症状、降低死亡率方面具有一定的疗效。
Objective To observe the mend matters of sepsis and intervention effects of death rate with Tanreqing Injection.Methods 90 sepsis patients in our hospital from May 2013 to May 2016 were selected and divided into Observation group and control group by the method of random number table,45 cases in each group.The control group was treated with normal western medicine,while the observation group was treated with Tanreqing Injection additional on the basis of normal western medicine.After 7 days of treatment,the changes of inflammatory marks including CRP,PCT,IL-6, IL,8,TNF-α were observed.APACHE II was recorded before and after treatment,After 21 days of treatment,the curative effect and death rate were counted.Results After 7 days of treatment,the observation group had better improvement effects on CRP,PCT,IL-6,IL-8,TNF-a than the control group,with statistically significant differences （P〈0.05）.The APACHE II score of the observation group was lower than that of the control group （P〈0.05）.After 21 days of treatment,efficiency rate of observation group （44.4%） was higher than the control group （28.9%）,with statistically significant differences（P〈0.05）. There were no statistically significant differences between two groups in the death rate （P〉0.05）.The observation group had lower incidence rates of shock and deep venous thrombosis than the control group with statistically significant differences （P〈0.05）.Conelusion Tanreqing Injection can reduce sepsis patients＇ inflammation,improve clir6cal symptoms and cut the death rate：
作者
黄雪敏
HUANG Xue-min ICU Guangji(Hospital of Hezhou City,Guangxi Zhuang Autonomous Region,Hezhou 542899,Chin)
出处
《中国当代医药》
2017年第15期25-27,共3页
China Modern Medicine
关键词
痰热清注射液
脓毒症
炎症反应
病情改善
疗效
Tanreqing lnjectipn
Sepsis
Inflammatory reaction
Condition improvement
Curative effect
