摘要
目的评价左氧氟沙星联合金双歧治疗急性腹泻的临床疗效及安全性。方法 65例急性腹泻患者随机分为对照组32例和试验组33例。2组患者均给予止吐、退热以及补充营养等对症治疗,对照组采用左氧氟沙星注射液10 m L~＋5%葡萄糖液250m L,1次/d,静脉滴注,3 d为1个疗程;试验组在此基础上联用双歧杆菌乳杆菌三联活菌片4片口服,3次/天,3 d为1个疗程。治疗结束后比较2组患者临床疗效、不良反应发生率、血清TNF-α、IL-6、CD4~＋、CD8~＋以及CD4~＋/CD8~＋水平。结果试验组总有效率96.27%明显高于对照组84.38%,差异具有统计学意义（P〈0.05）,2组不良反应发生率比较差异无统计学意义;治疗后2组患者血清TNF-α和IL-6水平降低（P〈0.05）,且试验组血清TNF-α和IL-6水平较低（P〈0.05）;治疗后2组患者CD4~＋水平下降（P〈0.05）,且试验组CD4~＋水平较低（P〈0.05）;CD4~＋/CD8~＋水平升高（P〈0.05）,且试验组CD4~＋/CD8~＋水平较高（P〈0.05）。结论左氧氟沙星联合金双歧治疗急性腹泻临床疗效显著,安全性高。
Objective To evaluate the efficacy and safety of Levofloxacin combined triple viable bacteria tablets of Lactobacillus in the treatment of acute diarrhea.Methods65 cases of acute diarrhea patients were randomly divided into control group with 32 cases and experiment group of 33 cases.Patients were given antiemetic, fever and nutritional supplements and other symptomatic treatment,the control group was treated with ofloxacin injection 10mL＋5% glucose solution 250mL for an intravenous injection, 3 days as a course of treatment;The experiment group was treated on the basis of triple viable bacteria tablets of Lactobacillus 4 tablets, 3 times a day, 3 days for a course of treatment.Clinical curative effect, adverse reaction rate, serum TNF-α, IL-6, CD4＋, CD8＋ and CD8＋ CD4＋/ level were compared.ResultsThe total effective rate in the experimental group was significantly higher than that in control group（P〈0.05）, there was no significant difference in the incidence of adverse reactions between the two groups.The levels of IL-6 and TNF-α were decreased in 2 groups （P〈0.05）, the levels of CD4＋ in the two groups were decreased （P〈0.05）, and the CD4＋ level was lower in the experiment group （P〈0.05）;the CD4＋/CD8＋ level was increased （P〈0.05）, and the CD4＋/CD8＋ level was higher in the experiment group （P〈0.05）.ConclusionThe clinical efficacy of levofloxacin combined with triple viable bacteria tablets of Lactobacillus in the treatment of acute diarrhea is significant, and the safety is high.
出处
《中国生化药物杂志》
CAS
2017年第5期306-307,310,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
左氧氟沙星
金双歧
急性腹泻
临床疗效
安全性
levofloxacin
triple viable bacteria tablets of lactobacillus
acute diarrhea
clinical efficacy
safety
