摘要
目的探讨不同治疗方式对老年乳腺癌患者的治疗效果,分析影响治疗效果的因素。方法回顾性分析2012年3月~2013年10月在缙云县人民医院肿瘤外科接受治疗的老年乳腺癌患者的临床资料,并根据其治疗方式分为A、B、C 3组,其中A组采用乳腺癌改良根治术＋静脉化疗＋内分泌治疗,B组采用乳腺癌改良根治术＋内分泌治疗,C组采用乳腺包块切除术＋内分泌治疗。观察3组术后1年、2年和3年生存率的差异,比较不同临床病理特征的患者术后3年生存率的差异,分析影响患者术后生存率的因素。结果 3组患者术后1年、2年和3年生存率无明显差异;高分化、无淋巴结转移、浸润深度为T1＋T2、TNM分期为Ⅰ＋Ⅱ期、免疫组化非三阴的老年乳腺癌患者的3年生存率较高,而不同年龄和肿瘤直径患者的3年生存率无明显差异;将老年乳腺癌患者的年龄、分化程度、肿瘤直径、淋巴结转移、浸润深度、临床分期、免疫组化三阴作为自变量,将患者生存情况作为因变量进行多因素Logistic回归分析。统计分析可得,淋巴结转移、浸润深度和免疫组化三阴情况是影响患者治疗效果的危险因素,其OR值分别为4.412、5.138和4.085。结论不同治疗方式对改善老年乳腺癌患者术后生存率无明显影响,且淋巴结转移、浸润深度和免疫组化三阴情况是影响患者治疗效果的因素。
Objective To investigate the effects of different treatments on elderly patients with breast cancer, and to analyze the factors that affect the treatment effect.MethodsA retrospective analysis was used to analysis the clinical data of elderly patients with breast cancer treated in our hospital from March 2012 to October 2013 were selected as the study object and according to the treatment methods, which were divided into three groups （A, B, C, which a group by breast modified radical surgery combined with intravenous chemotherapy and endocrine therapy, group B with breast modified radical mastectomy＋endocrine therapy, group C with breast mass resection and endocrine therapy.The differences of survival rate of 1 groups after three years, 2 years and 3 years were observed, and the difference of survival rate of patients with different clinical pathological characteristics after 3 years was compared.The factors influencing the survival rate of patients after operation were analyzed.ResultsThere was no significant difference in survival rate between the three groups after 1 years, 2 years and 3 years;High differentiation, lymph node metastasis, depth of invasion, T1＋T2, TNM stage I＋II, immune group of non Yin in the elderly patients with breast cancer of the 3 year survival rate was higher, while patients of different age and diameter of the tumor patients and 3 years survival rate had no significant difference;Will the elderly breast cancer patients age, differentiation degree, tumor size, lymph node metastasis, depth of invasion, clinical stage, immune group of three yin as independent variables, will survival in patients with multi factors logistic regression analysis was used.Statistical analysis available, lymph node metastasis, infiltration depth and the three Yin of the immune group were the risk factors affecting the treatment effect of patients, their OR values were 4.412, 5.138 and 4.085.ConclusionDifferent treatment methods have no significant effect on the survival rate of elderly patients with breast cancer, and lymph node metastasis, depth of invasion and the three Yin of the immune group are the factors that affect the treatment effect.
出处
《中国生化药物杂志》
CAS
2017年第5期425-427,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
乳腺癌
老年
改良根治术
生存率
危险因素
breast cancer
elderly
modified radical mastectomy
survival rate
risk factors
