摘要
目的了解妊娠期碘营养状态,及其与甲状腺功能的关系。方法随机选择于2016年6-10月接受妊娠期检查的孕妇295例,采用化学发光法检测血清游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)水平,采用碘催化砷铈反应检测尿碘水平。结果 295例孕妇尿碘水平中位数为174.90μg/L。碘缺乏和碘过量孕妇分别占40.00%和7.12%。与碘适量孕妇相比,碘缺乏及碘过量孕妇TPOAb阳性率和甲状腺疾病发生率均显著升高(P<0.05)。与碘适量孕妇相比,碘过量孕妇TSH和FT4水平明显升高(P<0.05)。结论妊娠期碘不足或碘过量较为常见,维持适量的尿碘水平对预防甲状腺功能异常十分重要。
Objective To analyze iodine nutrition and its correlation with thyroid function in pregnant women.Methods A total of 295 pregnant women were enrolled from Jun.to Oct.2016,and detected for serum levels of thyroid stimulating hormone(TSH),free thyroxine(FT4)and thyroid-peroxidase antibody(TPOAb)by using electrochemiluminescence analysis,and for urinary iodine concentration(UIC)by cold digestion method according to iodine catalytic effect of arsenic-cerium.Results The median of UIC was 174.90μg/L.The prevalence of iodine deficiency and iodine excess were 40.00% and 7.12%respectively.The prevalence of TPOAb positivity and thyroid dysfunction in the iodine deficiency group and iodine excess group were significantly higher than those of iodine proper group(P<0.05).The levels of TSH and FT4 of iodine excess group were significantly higher than those of iodine proper group(P<0.05).Conclusion The abnormality of iodine nutrition could be common in pregnant women.Monitoring of UIC and thyroid hormones should be highlighted.
出处
《国际检验医学杂志》
CAS
2017年第11期1490-1492,共3页
International Journal of Laboratory Medicine
关键词
尿碘
甲状腺功能
甲状腺过氧化物酶抗体
妊娠
urinary iodine
thyroid function
thyroid-peroxidase antibody
pregnancy
