摘要
目的探讨血清腺苷脱氨酶(ADA)在急性淋巴细胞白血病(ALL)辅助诊断中的临床价值。方法选取治疗前初诊的ALL患者98例为ALL组,完全随机抽取体检健康志愿者69例为健康对照组,检测两组血清ADA水平。结果 ALL组患者的ADA水平明显高于健康对照组(Z=-7.559,P<0.01);肝功能正常的ALL患者与健康对照组及肝功能异常ALL患者血清ADA水平差异有统计学意义(Z=-7.226,P<0.01;Z=-2.815,P=0.005)。55例ALL患者治疗前和治疗后ADA差异无统计学意义(Z=-0.038,P=0.970);采用受试者工作特征曲线(ROC曲线)确定最佳截点,将治疗前患者分为低ADA组(ADA<15.35U/L)和高ADA组(ADA≥15.35U/L),两组年龄差异有统计学意义(Z=-2.085,P=0.037),而两组肝功能指标(ALT、AST和GGT)差异无统计学意义(P>0.05)。结论 ALL患者ADA水平明显增加,治疗前后ADA水平无明显差异,患者ADA水平升高与年龄有关,提示ADA在ALL患者辅助诊断中存在一定价值。
Objective To explore the clinical value of serum adenosine deaminase （ADA） in the auxiliary diagnosis of acute lym- phocytic leukemia （ALL）. Methods A total of 98 pretherapy ALL patients were selected as the ALL group and 69 volunteers un- dergoing physical examination were randomly extracted as the control group. Serum ADA level in the two groups was detected. The differences of ADA levels were compared between ALL patients with normal liver function and healthy controls or ALL patients with abnormal liver function. The ADA level changes were compared between before and after treatment in 55 ALL patients. Using receiver operating characteristic （ROC） curve determined the best cutoff point of ADA. The ALL patients before treatment were di- vided into the low ADA group and high ADA group. Then the differences in age, gender, aspertate aminotransferase （AST）, alanlne aminotransferase （ALT） and gamma glutamyl transpeptidase （GGT） were compared between the two groups. Results The ADA level in the ALL group was significantly higher than that in the healthy control group （Z=--7. 559 ,P-0.01）. The ADA level had statistical difference between the ALL patients with normal liver function and healthy controls or ALL patients with abnormal liver function （Z=-7. 226 ,P〈0.01;Z=- 2. 815, P= 0.005）. The ADA level had no statistical difference between before and after treatment in the ALL patients （Z：- 0. 038,P=0. 970）; using ROC curve for determining the best cutoff point of ADA,the pretherapy patients were divided into the low ADA group （ADA〈15.35 U/L） and high ADA group（ADA≥15.35 U/L）,the age difference between the two groups had statistical significance （Z=- 2. 085, P=0. 037）, while the liver function indicators showed no statistical difference between the two groups （P〉0.05）, Conclusion The ADA level was significantly increased in ALL patients,which had no significant difference between before treatment and after treatment, the ADA level increase in ALL patients was associated with age,indicating that ADA has a certain value in the auxiliary diagnosis of ALL.
出处
《检验医学与临床》
CAS
2017年第11期1539-1541,共3页
Laboratory Medicine and Clinic
基金
山东省科学技术发展计划资助项目(2014GGH218041)
关键词
急性淋巴细胞白血病
腺苷脱氨酶
受试者工作特征曲线
年龄
肝功能
acute lymphocytic leukemia
adenosine deaminase
receiver operating characteristic curve
age
liver function
