摘要
目的:探讨结直肠癌患者采用扶正消癌汤联合治疗临床疗效,并观察其对患者免疫功能和临床症状及生活质量的影响。方法:回顾性分析医院2009年1月—2015年12月182例经手术组织病理学诊断为晚期结直肠癌患者临床诊治资料,其中以化疗、热疗治疗者为对照组;于对照组治疗基础上辅以中药扶正消癌汤治疗者为治疗组,每组各91例。于治疗后评价两组患者临床疗效,采用美国西北大学转归研究与教育中心的Celia等研制的癌症治疗功能评价系统中结直肠癌量表评价患者治疗前、后生活质量评分情况;于治疗前、后分别检测两组患者免疫功能、肿瘤标志物变化,评价两组临床中医证候积分、疼痛变化,记录两组治疗期间不良反应情况。结果:两组患者治疗后各项生活质量指标(躯体状况、社会或家庭状况、情感状况、功能状况、肠癌特异板块)评分明显高于治疗前,治疗组各项生活质量指标评分明显高于对照组,P<0.05;对照组CD_4^+细胞、CD_4^+/CD_8^+及NK细胞水平较治疗前明显下降,P<0.05;且与治疗组比较,P<0.05。两组患者治疗后肿瘤标志物CEA、CA199、CA242水平明显低于治疗前,治疗组各项肿瘤标志物水平明显低于对照组,P<0.05。治疗组治疗后中医证候积分为(10.15±3.18)分,明显低于对照组(14.96±4.25)分,t=8.64,P=0.00;治疗组治疗后VAS评分为(2.14±0.35)分,明显低于对照组(2.69±0.47)分,t=8.95,P=0.00;两组患者治疗后中医证候积分、VAS评分明显低于治疗前,P<0.05。治疗组治疗总有效率76.92%,明显高于对照组47.25%,χ~2=17.04,P=0.00;两组不良反应率相比,P>0.05。结论:采用中药扶正消癌汤联合化疗辅助治疗结直肠癌患者可有利于改善其临床症状,减轻其疼痛,提高其免疫功能,更好的提高患者生活质量。
Objective： To investigate the clinical efficacy of Fuzheng Xiaoai Decoction combined with chemotherapy in colorectal cancer patients and observe its effect on immune function and clinical symptoms and quality of life of patients.Methods： The clinical data of 182 patients with advanced colorectal cancer diagnosed by operation histopathology was analyzed retrospectively from Jan. 2009 to Dec. 2015. The patients were treated with chemotherapy and hyperthermia as the control group with 91 cases in each group. On the basis of the control group,the treatment group was treated with Fuzheng Xiaoai Decoction. After treatment,the clinical efficacy of the two groups was evaluated. The colorectal cancer scale was used to evaluate the quality of life of patients before and after treatment by Cancer Research and Education Center. The changes of immunological function and tumor markers were detected in 2 groups. The clinical symptoms and pain changes were recorded in 2 groups. The adverse reactions were recorded during the treatment. Results： The scores of quality of life（ physical condition,social or family status,emotional status,functional status,and intestinal cancer specificity） of the two groups after treatment were significantly higher than those before treatment and the scores of the quality of life of the treatment group were significantly higher than those of the control group（ P〈0. 05）. The levels of CD4^＋,CD4^＋/CD8^＋ and NK cells in control group were significantly lower than those before treatment（ P〈0. 05） and the levels of CEA,CA199 and CA242 in treatment group. The levels of tumor markers in the treatment group were significantly lower than those in the control group（ P〈0. 05）. The score of TCM syndrome after treatment in the treatment group was（ 10. 15 ± 3. 18） points,which was significantly lower than that in the control group（ 14. 96 ± 4. 25）,t = 8. 64,P =0. 00. VAS score of the treatment group was（ 2. 14 ± 0. 35）（ 2. 69 ± 0. 47）,t = 8. 95,P = 0. 00. The scores of TCMsyndrome and VAS in the two groups were significantly lower than those before treatment（ P〈0. 05）. The total effective rate in the treatment group was 76. 92%,which was significantly higher than that in the control group＇s 47. 25%,χ^2=17. 04,P = 0. 00. Conclusion： Fuzheng Xiaoai Decoction combined with chemotherapy in the treatment of colorectal cancer patients may be helpful to improve their clinical symptoms,reduce their pain,improve their immune function and better improve the quality of life of patients.
出处
《中华中医药学刊》
CAS
北大核心
2017年第6期1617-1620,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
结直肠癌
扶正消癌汤
生活质量
疼痛
化疗
colorectal cancer
Fuzheng Xiaoai Decoction
quality of life
pain
chemotherapy
