摘要
目的观察高压氧联合神经节苷脂（申捷）治疗重型颅脑损伤的临床疗效。方法按治疗方法将158例重型颅脑损伤患者分为A组（常规治疗）、B组（常规＋高压氧治疗）、C组（常规＋申捷治疗）、D组（常规＋高压氧＋申捷治疗） ,根据格拉斯哥昏迷量表（Glasgow coma scale, GCS）评分、格拉斯哥预后量表（Glasgow outcome scale, GOS）分级和总有效率评估疗效。结果D组患者治疗后GCS评分以及伤后6个月总有效率（93.48%）与C、B、A组（77.14%、77.78%、53.13%）比较差异有统计学意义（P〈0.05）。结论高压氧联合申捷治疗重型颅脑损伤可提高临床疗效，改善预后，减少后遗症。
ObjectiveTo observe the clinical efficacy of hyperbaric oxygen （HBO） associated with ganglioside-1 （GM-1） on severe brain injury.MethodsIn accordance with different treatment methods, 158 cases of severe craniocerebral injury were divided into group A （the routine therapy group）, group B （the routine therapy＋ HBO group）, group C （the routine therapy＋ GM-1 group） and group D （the routine therapy＋ HBO＋ GM-1 group）. Therapeutic efficacy was evaluated by the approaches of Glasgow coma scale （GCS） scores and Glasgow outcome scale（GOS） grades and total effective rate.ResultsThe GCS scores and total effective rate （93.48%）of the HBO associated with GM-1 group after treatment and 6 months after injury were obviously better than those of the other groups（77.14%, 77.78%, 53.13%）, and statistical significance could be noted, when comparisons were made between them （P〈0.05）ConclusionsHBO combined with GM-1 in the treatment of severe brain injury could enhance clinical efficacy, improve prognosis and reduce incidence of sequelae.
作者
陈健实
郭剑峰
孙雪峰
Chen Jianshi Guo Jianfeng Sun Xuefeng(First Hospital Affiliated to Xiamen University, Xiamen 361000, China)
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2017年第2期123-126,共4页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
高压氧
神经节苷脂
重型颅脑损伤
Hyperbaric oxygen
Ganglioside-1
Severe brain injury
