摘要
甲胎蛋白（alpha-fetal protein，AFP）是一种糖蛋白，自发现伊始，甲胎蛋白一直在相关儿童肿瘤（肝母细胞瘤、卵黄囊瘤、胰母细胞瘤等）的临床诊断中起到重要作用，但诊断作用并不完美，甲胎蛋白有三种异质体（AFP-L1，AFP-L2，AFP-L3），近年来，对其作用机制及功能的研究愈发加深。
Alpha-fetoprotein （AFP） has been used as an important tumor marker for hepatoblastoma （HB） and malignant germ cell tumors （GCTs） in pediatric patients. With a low diagnostic specificity, it has 3 isoforms of AFP-L1, AFP-L2 and AFP-L3. This review summarizes recent advances in researches on AFP and its variants.
Key words Alpha-fetoprotein; Protein isoforms; Neoplasms; Hepatoblastoma
作者
黄一晋
王焕民
Huang Yijin Wang Huanmin(Department of Surgical Oncology , Affiliated Beijing Children＇ s Hospital, Capital Medical University, Beijing 100045, China)
出处
《中华小儿外科杂志》
CSCD
2017年第5期395-398,共4页
Chinese Journal of Pediatric Surgery
