摘要
目的:观察榄香烯乳单药腔内注射治疗难治性卵巢癌恶性胸腹水的临床疗效。方法:2010年1月至2016年6月在长海医院中医妇科收治的难治性卵巢癌胸腹水患者12例,给予榄香烯乳单药进行胸腹腔注入,对其临床疗效、不良反应等进行回顾性分析。结果:12例患者中完全缓解6例(50%),部分缓解3例(25%),无效3例(25%),总有效率达75%。不良反应主要为发热、胸闷胸痛、腹痛、恶心呕吐等,均经对症处理后好转。结论:榄香烯乳胸腹腔单药注入对于晚期、体弱、铂类耐药的卵巢癌患者安全有效,值得临床治疗卵巢癌晚期胸腹水病例的推广应用。
Objective: To evaluate the therapeutic effect of the treatment of malignant pleuroperitoneal fluid of refractory ovarian cancer with elemene injection. Methods: From January 2010 to June 2016,12 clinical cases of refractory ovarian cancer with malignant pleuroperitoneal fluid,hospitalized in Changhai Hospital,were injected with elemene into chest and abdomen. The clinical and toxic side effects of these cases were analyzed retrospectively. Results: In 12 cases,6 cases got ease( 50%),partial remission 3 cases( 25%) and invalid 3 cases( 25%). Total effective rate was 75%. The major toxic side effects were fever,chest distress,chest pain,abdominal pain,nausea and vomiting. All the toxic side effects were improved after symptomatic treatment. Conclusion: Elemene injecting into chest and abdomen is safe and effective for treatment of the refractory ovarian cancer with malignant pleuroperitoneal fluid,worthy of clinical application.
出处
《现代肿瘤医学》
CAS
2017年第14期2288-2290,共3页
Journal of Modern Oncology
基金
国家自然科学基金(编号:81202963
81603651)
上海市进一步加快中医药事业发展三年行动计划(编号:ZY3-CCCX-3-7002)
CSCO-恒瑞肿瘤研究基金(编号:Y-HR2015-244)
关键词
榄香烯乳
难治性卵巢癌
恶性胸腹水
铂类耐药
elemene
refractory ovarian cancer
malignant pleuroperitoneal fluid
platinum resistance
