高血压患者以右美托咪定麻醉的苏醒期躁动和血流动力学分析被引量：1

导出

摘要目的分析在高血压患者手术中运用右美托咪定麻醉苏醒期躁动发生率及患者血流动力学受影响的情况。方法对80例高血压手术患者进行观察,所有患者均采用静吸复合麻醉。采用随机数字表法将所有患者分为观察组、对照组,对照组中40例患者静脉泵泵注生理盐水,观察组中40例患者静脉泵注盐酸右美托咪定。记录两组患者用药前(T1)、用药10min后(T2)、拔管时(T3)、拔管10min后(T4)的平均动脉压(MAP)、呼吸频率(RR)、心率(HR)变化情况及术后1h的疼痛程度(VAS评分)、苏醒期躁动发生率。结果两组患者在T2、T3时MAP、RR、HR明显低于T1,且观察组各项指标明显更低(P<0.05);T4时各项指标明显回升,观察组各项指标与T1无明显差异(P>0.05);观察组VAS评分、苏醒期躁动发生率明显低于对照组(P<0.05)。结论右美托咪定的镇静效果平稳,术后患者疼痛轻,苏醒期躁动发生率低。

作者王贵罗

机构地区河南省南阳市第二人民医院

出处《首都食品与医药》 2017年第12期95-96,共2页 Capital Food Medicine

关键词高血压右美托咪定苏醒期躁动血流动力学

分类号 R614 [医药卫生—麻醉学]

引文网络
相关文献

参考文献4

1张杰.右美托咪定复合地佐辛防治老年高血压肺癌全麻苏醒期躁动[J].中国中西医结合外科杂志,2016,22(3):256-258. 被引量：19
2谢晓玲,成国荣,谢宝容.右美托咪定预防高血压患者全麻苏醒期躁动和心血管反应的临床观察[J].中国现代医生,2014,52(8):77-79. 被引量：31
3罗颖,周小莲,金芊芊,吴艳辉,丁卫华.右美托咪定对老年高血压患者全麻拔管期应激反应及苏醒时间的影响[J].中华全科医学,2014,12(2):171-173. 被引量：28
4汪延斌,冯宇峰,林梁.不同剂量右美托咪定对全麻食道癌患者术后苏醒期的影响[J].中国实用医药,2013,8(25):9-11. 被引量：3

二级参考文献49

1Okawa K,Ichinohe T,Kaneko Y.A comparison of propofol and dexmedetomidine for intravenous sedation:a randomized,crossover study of the effects on the central and autonomic nervous systems.Anesth Analg,2010,110(2):415-418.
2Chen BS,Peng H,Wu SN.Dexmedetomidine,an α2-adrenergic agonist,inhibits neuronal delayed-rectifier potassium current and sodium current.Br J Anaesth,2009,103 (2):244-254.
3Huupponen E,Maksimow A,Lapinlampi P,et al.Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep.Acta Anaesthesiol Scand,2008,52 (2):289-294.
4Angst MS,Ramaswamy B,Davies MF,et al.Comparative analgesic and mental effects of increasing plasma concentrations of dexmedeto-midine and alfentanil in humans.Anesthesiology,2004,101 (3):744-752.
5Pypendop BH,Barter LS,Stanley SD,et al.Hemedynamic effects of dexmedetomidine in isoflurane-anesthetized cats.Vet Anaesth Analg,2011,38(6):555-567.
6Turgut N,Turkmen A,Gokkaya S,et al.Dexmedetomidine-based versus fentanyl-based total intravenous anesthesia for lumbar laminectomy.Minerva Anestesiol,2008,74(9):469-74.
7Su F,Hammer GB.Dexmedetomidine:pediatric pharmacology,clinical uses and safety.Expert Opin Drug Saf,2011,10 (1):55-66.
8Arain SR,Ruehlow RM,Uhrich TD,et al.The efficacy of dexme-detomidine versus morphine for postoperative analgesia after major inpatient surgery.Anesth Analg,2004,98(1):153-158.
9Dave J,Vaghela S.A comparison of the sedative,hemodynamic,and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging.Saudi J Anaesth,2011,5(3):295-9.
10Ngwenyama NE,Aanderson J,Hoernschemeyer DG,et al.Effects of dexmedetomidine on propofol and remifentanil infusion rates during total intravenous anesthesia for spine surgery in adolescents.Paediatr Anaesth,2008,18 (12):1190-1195.