摘要
鼠类肉瘤滤过性毒菌致癌同源体B(v-raf murine sarcoma viral oncogene homolog B,BRAF)是一个重要的丝氨酸/苏氨酸激酶,由它参与的丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路调控细胞的增殖、分化和凋亡。BRAF基因突变发生在许多恶性肿瘤中,与这些肿瘤的发生及发展密切相关。成釉细胞瘤是一种常见的局部侵袭性生长的良性牙源性肿瘤,2014年,该基因被证实在成釉细胞瘤中存在高突变率,从此开始了成釉细胞瘤分子病理研究的时代,并为肿瘤靶向治疗的研究带来希望。该文就BRAF基因突变在肿瘤(尤其是成釉细胞瘤)中的研究及MAPK信号通路的作用作一综述。
V-raf murine sarcoma viral oncogene homolog B（BRAF） is a serine/threonine kinase with a key role in the mitogen-activated protein kinase（MAPK） pathway which regulates cell proliferation, differentiation and apoptosis. Several mutations have been observed in the gene coding area in a variety of human malignancies. Ameloblastoma is a benign but locally infiltrative odontogenic tumor, and a high frequency of BRAF mutations in ameloblastoma was reported in 2014, the highlight affair offer an expectation for future application of BRAFtargeted therapeutics. In this review we give an update on the clinical pathological and biological characteristics relevance of BRAF mutation and MAPK pathway in tumor, especially in ameloblastoma.
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第5期668-674,共7页
Chinese Journal of Cell Biology
基金
河北省科技厅项目(批准号:15277762D)资助的课题~~
