摘要
酒精性肝病(alcoholic liver disease,ALD)是一种慢性肝脏疾病,包括肝脂肪变性、酒精性脂肪性肝炎、肝硬化、肝细胞癌和肝衰竭.许多因素被认为能促进ALD的发展,特别是氧化应激,在酒精代谢期间活性氧物质的产生,来自内脏脂肪组织的脂肪因子和来自肠道的内毒素等.目前,ALD的发病机制已被广泛研究,精确的机制尚待阐明.在我国随着人类生活水平提高和生活方式的改变,人群中的嗜酒者的比率逐年上升,乙醇也已成为导致肝脏损害的第二大原因.因此,ALD相关治疗也受到人们的广泛关注.在本文中,我们就ALD的发病机制、治疗等方面的最新研究进展作一综述.
Alcoholic liver disease （ALD） is a chronic liver disease, and it includes hepatic steatosis, alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and liver failure. Many factors are thought to contribute to the development of ALD, particularly oxidative stress, generation of reactive oxygen species during alcohol metabolism, adipokines from visceral adipose tissue, and endotoxin derived from the gut. Currently, although the pathogenesis of ALD has been widely investigated, the precise mechanisms remain to be elucidated. With the improvement of human living standard and the change of lifestyle in China, the population of alcoholics has increasingly risen, and alcohol consumption ranks second among the etiologies of liver disease. Therefore, ALD treatment has attracted widespread attention. This paper will review the latest research on the risk factors and treatment of ALD.
出处
《世界华人消化杂志》
CAS
2017年第15期1382-1388,共7页
World Chinese Journal of Digestology
关键词
酒精性肝病
发病机制
治疗
Alcoholic liver disease
Pathogenesis
Treatment
