摘要
目的探究腹腔镜手术治疗良性卵巢肿瘤的疗效及对患者免疫功能与神经内分泌功能的影响。方法选取驻马店中医院2013年7月—2016年3月收治的82例良性卵巢肿瘤患者,依据手术方案不同分为对照组与研究组,各41例。对照组展开传统开腹手术,研究组行腹腔镜手术治疗。观察两组手术用时、术中出血量、退热、术后排气及留院观察时间,并对比两组手术前后免疫功能(CD^(3+)、CD^(4+)、CD^(4+)/CD^(8+)、CD^(8+))、卵巢功能[FSH(促卵泡激素)、LH(黄体生成素)、E2(雌二醇)]及神经内分泌功能(皮质醇、胰高血糖素、Β-内啡肽)指标变化情况。结果两组手术用时差异无统计学意义(P>0.05);与对照组相比,研究组退热、术后排气及留院观察时间较短,术中出血量较少,差异有统计学意义(P<0.05);两组术前免疫功能指标水平差异均无统计学意义(P>0.05),与对照组相比,研究组术后CD^(3+)、CD^(4+)/CD^(8+)、CD^(4+)水平均较高,CD^(8+)水平较低,差异有统计学意义(P<0.05);两组术前卵巢功能指标水平差异无统计学意义(P>0.05),与对照组相比,研究组术后FSH、LH水平较高,E2水平较低,差异有统计学意义(P<0.05);两组术前神经内分泌功能指标水平差异无统计学意义(P>0.05),与对照组相比,研究组术后神经内分泌功能指标水平均较低,差异有统计学意义(P<0.05)。结论腹腔镜手术应用于良性卵巢肿瘤治疗中,术中出血少,术后恢复快,且可显著改善患者卵巢功能,有效缓解免疫反应抑制及神经内分泌功能兴奋情况。
Objective To explore the effect of laparoscopic surgery on benign ovarian tumors and its effect on patients immune function and neuroendocrine function. Methods From July 2013 to March 2016, 82 patients with benign ovarian cancer in our hospital were divided into control group and study group according to treatment plan, 41 cases each group. The control group was treated with conventional laparotomy, and the study group was treated with iaparoscopic surgery. Operation time, intraoperative blood loss, fever, postoperative exhaust and hospital observation time were analyzed, immune function （ CD3 ＋ , CD4 ＋ , CD4 ＋/CD8 ＋ , CD8 ＋ ） , ovarian function [ FSH （ follicle stimulating hormone）, LH （ luteinizing hormone）, E2 （estradiol） ] and neuroendocrine function （ cortisol, pancreas Glucagon, beta - endor- phin） before and after surgery were compared as well. Results There was no significant difference in operation time between the two groups （ P 〉0. 05 ） ; Compared with the control group, the fever, postoperative exhaust and hospital observation time of the study group is shorter and less intraoperative blood loss, the difference was statistically significant （ P 〈 0. 05 ） ; There was no significant difference in the level of immune function before operation （ P 〉 0. 05 ）, compared with the control group, the levels of CD3＋ , CD4＋/CDS＋ and CD4＋ in the study group were higher than those in the con- trol group, the difference was statistically significant （ P 〈 0.05 ） ; There was no significant difference in the level of ovarian function before operation （P 〉0. 05）, compared with the control group, the levels of FSH and LH in the study group were higher than those in the control group, E2 levels were lower than the control group, and the difference was statistically significant （P 〈 0. 05 ） ; There was no significant difference in preoperative neuroendocrine function between the two groups （ P 〉 0. 05 ） , compared with the control group, the levels of neuroendocrine function were lower in the study group after operation, the difference was statistically significant （ P 〈 O. 05 ）. Conclusion Laparoscopic surgery in the treatment of benign ovarian tumors gets less intraoperative bleeding, the postoperative recovery is quick, it can sig- nificantly improve patient＇ s ovarian function, effectively alleviate patients immune response and neuroendocrine function excitement.
出处
《医药论坛杂志》
2017年第4期60-62,共3页
Journal of Medical Forum
关键词
腹腔镜手术
良性卵巢肿瘤
免疫功能
神经内分泌功能
Laparoscopic surgery
Benign ovarian neoplasms
Immune function
Neuroendocrine function
