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单倍型相合造血干细胞移植“北京方案” 被引量:2

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摘要 造血干细胞移植(HSCT)是治疗白血病等恶性血液疾病有效乃至唯一的治愈方式[1].由于免疫排斥反应的原因,长期以来,以免疫抑制药物诱导免疫耐受,HSCT仅局限于HLA全相合同胞或非血缘供者.供者来源缺乏一直是限制HSCT推广和应用的重大临床问题.另一方面,几乎所有患者均有单倍型相合供者.单倍型相合移植供者指的是:供、受者二倍体细胞之间有一条全长DNA单倍体相同,父母和子女一条单倍体相合的几率为100%,而同胞之间一条单倍体相合的几率则为75%.采用单倍型相合供者进行的HSCT即为单倍型相合HSCT.
作者 黄晓军
出处 《中华器官移植杂志》 CAS CSCD 2017年第2期65-68,共4页 Chinese Journal of Organ Transplantation
基金 基金项目:国家自然科学基金(81230013,81530046,81621001)
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