摘要
目的探讨重组牛碱性成纤维细胞生长因子对老年糖尿病性白内障超声乳化术患者临床症状及视觉恢复的影响,分析其可能的作用机制。方法选择2014年8月至2015年7月拟行白内障超声乳化术的76例(87眼)老年糖尿病性白内障患者为研究对象,采用随机数字表法分为观察组38例(44眼)和对照组38例(43眼),所有患者术后均用妥布霉素地塞米松滴眼液点眼15 d,对照组联合聚乙二醇滴眼液点眼,观察组联合重组牛碱性成纤维细胞生长因子滴眼液点眼。比较2组泪膜稳定性相关指标、干眼主观症状、最佳矫正视力等指标。结果术后1周时,观察组角膜荧光素染色(FL)、基础泪液分泌试验(SIt)明显低于对照组,泪膜破裂时间(BUT)明显高于对照组(t=6.529~13.454,P<0.05,P<0.01);术后1、7 d,1个月时,干眼主观症状评分均明显低于对照组(t=4.767~22.115,P<0.05,P<0.01);术后3个月,观察组最佳矫正视力明显高于对照组(t=9.279,P<0.05),视力≥0.3占比93.18%明显高于对照组76.74%(χ2=4.623,P<0.05)。结论重组牛碱性成纤维细胞生长因子有助于促进糖尿病性白内障超声乳化术患者泪膜稳定性恢复,改善干眼主观症状,提高患者视力水平。
Objective To investigate the effect of recombinant bovine-basic fibroblast growth factor（rb-b FGF）on clinical symptoms and visual recovery in elderly patients underwent diabetic cataract phacoemulsification, and to analyze its potential mechanism. Methods Seventy-six patients（87 eyes） with diabetic cataract, who were scheduled for cataract phacoemulsification between August 2014 and July 2015, were included in this study. All patients were randomly divided into the study group（n=38, 44 eyes） and the control group（n=38, 43 eyes）, and were treated with Tobramycin dexamethasone eye drops for 15 d. The control group was combined with Polyethylene glycol eye drops,and the study group was combined with rb-b FGF eye drops. The tear film stability related indicators, subjective symptoms of dry eyes, best corrected vision were compared between two groups. Results At 1week after the operation, the corneal fluorescein staining（FL） and Schirmer I test（SIt） in the study group were significantly lower than those in the control group, whereas the tear film break-up time（BUT） was significantly longer than that in the control group（t =6.529~13.454, P〈0.05, P〈0.01）. At 1d, 7d, and 1 month after the operation, the dry eye subjective symptom scores in the study group was significantly lower than that in the control group（t=4.767~22.115, P〈0.05, P〈0.01）. At 3 months after the operation, the best corrected vision in the study group was significantly higher than that in the control group（t=9.279, P〈0.05）. The vision ≥0.3 accounted for 93.18% in the study group, which was significantly higher than76.74% in the control group（χ^2=4.623, P〈0.05）. Conclusion Rb-b FGF favors the recovery of tear film stability in patients underwent diabetic cataract phacoemulsification, and improvement of dry eye subjective symptoms and vision level.
出处
《中国药物与临床》
CAS
2017年第6期810-813,共4页
Chinese Remedies & Clinics
