摘要
目的:采用Meta分析评价高密度脂蛋白胆固醇与乳腺癌发生的相关性。方法:计算机检索PubMed、Ovid、EBSCO、Cochrane Library、中国知网、维普期刊资源整合服务平台、万方数据资源系统、中国生物医学文献数据库,收集自建库开始至2017年1月9日有关高密度脂蛋白胆固醇与乳腺癌发生相关性的研究。对符合纳入标准的研究进行资料提取。采用标准化均数差(standardized mean difference,SMD)作为效应指标。根据纽卡斯尔-渥太华量表进行文献质量评价。应用Stata 12.0软件进行Meta分析。结果:共纳入12项有关血清高密度脂蛋白胆固醇与乳腺癌发生相关性的研究,包括8 204例乳腺癌患者和230 835例对照者。Meta分析结果显示,血清高密度脂蛋白胆固醇水平与乳腺癌发生相关[SMD=-0.35(95%可信区间:-0.58^-0.12),P<0.001];亚组分析结果显示,绝经前乳腺癌患者的血清高密度脂蛋白胆固醇水平低于对照者[SMD=-0.15(95%可信区间:-0.29^-0.01),P=0.040],绝经后血清高密度脂蛋白胆固醇水平与乳腺癌发生无明显相关性[SMD=-0.44(95%可信区间:-0.98~0.11),P=0.110];在不同的研究地区,血清高密度脂蛋白胆固醇水平与乳腺癌发生的相关性不明确。结论:绝经前血清高密度脂蛋白胆固醇水平与乳腺癌发生相关,低水平的高密度脂蛋白胆固醇可能增加绝经前乳腺癌发生风险,绝经后乳腺癌的发生与血清高密度脂蛋白胆固醇水平的相关性不明确。鉴于纳入研究的局限性,对上述结论尚需开展更大样本量的前瞻性队列研究予以验证。
Objective： Meta-analysis was used to assess the association between serum high-density lipoprotein-cholesterol （HDL-C） level and the development of breast cancer.Methods： Studies on the relationship of high-density lipoprotein-cholesterol and the development of breast cancer were retrieved from PubMed, Ovid, EBSCO, Cochrane Library, China National Knowledge Internet, VIP Periodical Resource Integration Service Platform, Wanfang Database and China Biomedical Literature Database from inception to January 9, 2017. Data were extracted from studies which met the inclusion criteria. Standardized mean difference （SMD） was used as an indicator of effect. Literature quality evaluation was carried out according to Newcastle-Ottawa Scale. Stata 12.0 software was used for Meta-analysis.Results： A total of 12 studies on the association of serum HDL-C level with breast cancer were included in this Meta-analysis, including 8 204 patients with breast cancer and 230 835 controls. Meta-analysis showed that the serum HDL-C level was associated with breast cancer [SMD = –0.35 （95% confidence interval： –0.58 to –0.12）, P〈0.001]. Subgroup analysis revealed that serum HDL-C level of premenopausal breast cancer patients was lower than that of the controls [SMD = –0.15 （95% confidence interval： –0.29 to –0.01）, P= 0.040], but the postmenopausal serum HDL-C level had no obvious relationship with breast cancer [SMD = –0.44 （95% confidence interval： –0.98 to 0.11）, P= 0.110]. In different study regions, the relationship between serum HDL-C level and the development of breast cancer was not clear.Conclusion： HDL-C is related to premenopausal breast cancer, and low serum HDL-C level may increase the risk of premenopausal breast cancer. The relationship between postmenopausal breast cancer and HDL-C is not clear. Given the limitations of the included studies, a larger prospective cohort study is needed to validate the above findings.
出处
《肿瘤》
CAS
CSCD
北大核心
2017年第6期616-623,共8页
Tumor
基金
重庆市研究生教改课题(编号:yjg153068)~~
