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脓毒症相关凝血功能障碍机制及治疗的研究进展 被引量:29

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摘要 脓毒症是感染导致死亡的首要因素[1]。在美国,每年新出现约100万的脓毒症病例,造成20万人死亡[2]。随着治疗手段的不断进展,重症脓毒症28 d病死率已从1991~1995年的46.9%降至2006~2009年的29%[3]。
出处 《中华危重症医学杂志(电子版)》 CAS CSCD 2017年第2期125-129,共5页 Chinese Journal of Critical Care Medicine:Electronic Edition
基金 军队后勤科研计划重点项目(BHJ14C009)
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  • 1Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM / ESICM / ACCP / ATS / SIS international sepsis definitions [J]. Intensive Care Med, 2003, 29 (4): 530-538.
  • 2Thiolliere F, Serre-Sapin AF, Reignier J, et al. Epi- demiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study [J]. Intensive Care Med, 2013, 39 (8): 1460-1468.
  • 3Levi M, Lowenberg EC. Thrombocytopenia in critically ill patients [J]. Semin Thromb Hemost, 2008, 34 (5): 417-424.
  • 4Hui P1, Cook DJ, Lim W, et al. The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review [J]. Chest, 2011, 139 (2): 271-278.
  • 5Vandijck DM, Blot SI, De Waele JJ, et al. Throm- bocytoenia and outcome in critically ill patients with bloodstream infection [J]. Heart Lung, 2010, 39 (1): 21-26.
  • 6Thiele T, Selleng K, Selleng S, et al. Thrombocy- topenia in the intensive care unit-diagnostic approach and management [J]. Semin Hematol, 2013, 50 (3): 239-250.
  • 7Thiolliere F, Serre-Sapin AF, Reignier J, et al. Ep- idemiology and outcome of thrombocyto-penic patients in the intensive care unit: results of a prospective multicenter study [J]. Intensive Care Med, 2013, 39 (8): 1460-1468.
  • 8Annane D, Bellissant E, Cavaillon JM. Septic shock[J].Lancet, 2005, 365 (9453): 63-78.
  • 9Boechat TD, Silveira MF, Faviere W, et al. Throm- bocitopenia in sepsis: an important prognosis factor[J]. Rev Bras Ter Intensiva, 2012, 24 (1): 35-42.
  • 10Levi M, Schultz M. Cogulation and platelet disorders in critically ill patients [J]. Minerva Anestesiol, 2010, 76 (10): 851-859.

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