摘要
目的探讨低分子肝素对体外受精一胚胎移植(IVF-ET)中多次着床失败患者再次解冻移植助孕临床妊娠结局的影响。方法选择2015年1月至2016年12月在我院生殖中心行IVF-ET助孕中多次着床失败,再次解冻移植助孕患者共106例。再次胚胎解冻移植周期数为108周期,自胚胎移植日起,根据用药知情同意原则行随机对照研究,研究组50周期给予低分子肝素钠+常规黄体支持,对照组58周期只给予常规黄体支持。观察两组患者妊娠结局。结果两组患者年龄、体重指数、基础FSH值、移植胚胎数比较,差异均无统计学意义(P>0.05)。研究组和对照组临床妊娠率(36%VS 27.6%)、胚胎着床率(26.5%vs 19.5%),流产率(5.56%VS 6.25%)比较,差异无统计学意义(P>0.05)。结论低分子肝素对于反复种植失败患者不能显著其再次解冻移植周期的妊娠结局。
Objective： To explore the effect of Low-molecular-weight heparin on outcomes of thawed embryo transfer in women with repeated implantation failure （RIF） without pregnant while transplant quality embryos ≥ 3 times or total 4 high quality embryos. Methods： From January 2015 to December 2016, 106 women with RIF （ET ≥3 times or total 4 high quality embryos the embryos were planted failure） who planned to perform thawed embryo transfer （TET） again were included in the study.the number of TET cycles is 108 cycles.There were 50 cycles （49 cases） in study group received low-molecular-weight heparin （LMWH） and conventional luteal support on TET day of new embryo transfer cycles, while 58 cycles （57cases） in control group only received conventional luteal support. The outcomes of TET were compared between these two groups. Results： There were no significant differences between theses two groups in the age of the patients, BMI, basal level of FSH, and the number and quality of embryo transplant （P〉0.05） .There were no significant differences in embryo implantation rate （26.53%VS 19.49%） , clinical pregnancy rate （36.00%VS 27.59%） , abortion rate （5.56%VS 6.25%） between study group and control group （P〉0.05） . Conclusions： Low-molecular-weight heparin （LMWH） can not improve the clinical pregnancy rate and clinical pregnancy outcomes of TET in women with RIF.
出处
《中国优生与遗传杂志》
2017年第6期113-115,共3页
Chinese Journal of Birth Health & Heredity
关键词
体外受精-胚胎移植
低分子肝素钠
反复着床失败
解冻移植
妊娠结局
In vitro fertilization-embryo transfer
Low-molecular-weight heparin （LMWH）
Repeated implantation failure
Thawed embryo transfer
Outcomes
