摘要
目的 :研究铁代谢异常及细胞免疫功能紊乱与复发性口腔溃疡(recurrent oral ulcer,ROU)的内在联系。方法 :检测100例ROU患者和100例健康体检人员(对照组)血清铁、铁蛋白及其细胞免疫功能,比较2组间的差异,利用logistic回归分析血清铁蛋白及细胞免疫与复发性口腔溃疡的关系。采用SPSS19.0软件包对数据进行统计学分析。结果:ROU组男、女血清铁、铁蛋白、CD3^+、CD4^+及CD4^+/CD8^+比值浓度均出现降低,与对照组比较具有显著差异(P<0.01);多因素logistic回归分析显示,血清铁、铁蛋白及CD3^+、CD4^+降低均为ROU发病的独立危险因素(P<0.05)。结论:铁缺乏、细胞免疫功能紊乱与ROU发病关系密切。
PURPOSE： To study the relationship between abnormal iron metabolism and cellular immune dysfunction and recurrent oral ulcer. METHODS： A cross-sectional analysis of serum iron, ferritin and cellular immune function in 100 patients with recurrent oral ulcer and 100 healthy cases as control were performed. Logistic regression analysis was conducted to evaluate the relationship between serum ferritin and cellular immunity and recurrent oral ulcer using SPSS 19.0 software package. RESULTS： Serum iron, ferritin, CD3^＋, CD4^＋ and CD4^＋/CD8^＋ concentration significantly decreased in Rou group compared with the control group （P〈0.01）. Multiple logistic regression analysis showed serum iron, ferritin and CD3^＋, CD4^＋ decrease were the independent risk factors for the onset of ROU, whereas CD4^＋/CD8^＋ were the protective factors in the pathogenesis of ROU （P〈0.05）. CONCLUSIONS： Iron deficiency and cellular immune function is closely related to the pathogenesis of ROU.
作者
蓝余炼
唐亮
崔日林
LAN Yu-lian TANG Liang CUI Ri-lin.(Fuzhongfu Community Health Center, Center Hospital of Baoan District. Shenzhen 518102, Guangdong Province, China)
出处
《上海口腔医学》
CAS
CSCD
2017年第3期302-304,共3页
Shanghai Journal of Stomatology
基金
深圳市宝安区科技社会公益资助项目(2015072)
关键词
复发性口腔溃疡
铁缺乏
细胞免疫功能
Recurrent oral ulcer
Iron deficiency
Cellular immune function
