摘要
目的探究神经节苷酯联合氯吡格雷治疗脑梗死后血管性痴呆的临床疗效。方法选取2014年10月—2015年10月在中国人民解放军第三军医大学第一附属医院接受治疗的脑梗死后血管性痴呆患者126例,随机分为对照组和治疗组,每组各63例。对照组患者口服硫酸氢氯吡格雷片,75 mg/次,1次/d;治疗组在对照组的基础上静脉滴注单唾液酸四己糖神经节苷脂钠注射液,100 mg/次,1次/d,两组患者均治疗3个月。观察两组的临床疗效,比较两组治疗前后的简易智力状态检查量表评分、日常生活能力量表评分和临床痴呆评定量表评分及其不良反应情况。结果治疗后,对照组和治疗组的总有效率分别为76.19%、96.83%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者简易智力状态检查量表评分明显升高,日常生活能力量表评分和临床痴呆评定量表评分均明显降低,同组治疗前后差异具有统计学意义(P<0.05);治疗后治疗组简易智力状态检查量表评分明显高于对照组,治疗组日常生活能力量表评分和临床痴呆评定量表评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。两组不良反应发生情况比较差异无统计学意义。结论神经节苷酯联合氯吡格雷治疗脑梗死后血管性痴呆的疗效显著,安全性较好,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of ganglioside combined with clopidogrel in treatment of vascular dementia after cerebral infarction. Methods Patients（126 cases） with vascular dementia after cerebral infarction in the First Affiliated Hospital of Third Military Medical University from October 2014 to October 2015 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Clopidogrel Hydrogen Sulphate Tablets, 75 mg/time, once daily. Patients in the treatment group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 100 mg/time, once daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and simple intelligence status scale, the daily life ability scale, the clinical dementia rating scale, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.19% and 96.83% respectively, and there was difference between two groups（P〈0.05）. After treatment, the scores of simple intelligence status scale were significantly increased, but the scores of the daily life ability scale and the clinical dementia rating scale were significantly decreased, the difference was statistically significant in the same group（P〈0.05）. And the scores of simple intelligence status scale, daily life ability scale, and clinical dementia rating scale were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. There was no significant difference in adverse reactions between two groups. Conclusion Gangliosides combined with clopidogrel has a significant curative effect in treatment of vascular dementia after cerebral infarction with good safety, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2017年第5期788-791,共4页
Drugs & Clinic
